1644461-85-7

Basic information

• Product Name: (1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)aMino)-5-(propylsulfinyl)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
• Synonyms: (1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)aMino)-5-(propylsulfinyl)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol;Ticagrelor Sulfoxide;Ticagrelor Sulfoxide Impurity (Mixture of diastereomers);Ticagrelor Sulfoxide (Mixture of Diastereomers);(1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-propylsulfinyltriazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol;(1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylsulfinyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-dio
• CAS NO: 1644461-85-7
• Molecular Formula: C23H28F2N6O5S
• Molecular Weight: 538.5674264
• Mol File: 1644461-85-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 821.3±75.0 °C(Predicted)
• Appearance: /
• Density: 1.75±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: 13.25±0.70(Predicted)
• CAS DataBase Reference: (1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)aMino)-5-(propylsulfinyl)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)aMino)-5-(propylsulfinyl)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol(1644461-85-7)
• EPA Substance Registry System: (1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)aMino)-5-(propylsulfinyl)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol(1644461-85-7)

Safety Data

• Hazardous Substances Data: 1644461-85-7(Hazardous Substances Data)

Usage

Description

(1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylsulfinyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol is a complex organic compound with a unique molecular structure. It is characterized by its chiral centers and functional groups, which contribute to its specific properties and potential applications.

Uses

Used in Pharmaceutical Industry:
(1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylsulfinyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol is used as an impurity in the synthesis of ticagrelor, a reversible oral P2Y12 receptor antagonist. Ticagrelor provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel, making it an effective treatment for acute coronary syndromes (ACS). The presence of this compound as an impurity in ticagrelor may affect the drug's efficacy and safety, and its analysis and control are crucial in ensuring the quality of the final pharmaceutical product.

Upstream product

• 1006614-49-8 (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine 
• 376608-75-2 2-{[(3aR,4S,6R,6aR)-6-[7-chloro-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-hexahydrocyclopenta[1,3]dioxol-4-yl]oxy}ethanol 
• 376608-74-1 2-[((3aR,4S,6R,6aS)-6-[[5-amino-6-chloro-2-(propylsulfanyl)-4-pyrimidinyl]amino]-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy]-1-ethanol 
• 376608-75-2 2-({(3aR,4S,6R,6aS)-6-[7-chloro-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-3-yl]-2,2-dimethyltetrahydro-3aH-cyclopentadiene[d][1,3]dioxolene-4-yl}oxy)ethanol 
• 376608-74-1 C₁₇H₂₇ClN₄O₄S 
• 376608-75-2 C₁₇H₂₄ClN₅O₄S 

Relevant articles and documents

S-type chiral sulfoxide compound preparation method

The invention belongs to the field of chemical synthesis, and particularly relates to an S-type chiral sulfoxide compound preparation method, which mainly comprises four steps of cyclization, substitution, catalytic oxidation and hydrolysis removal of isopropylidene, wherein a catalytic oxidation reaction is carried out by adopting a certain catalyst and a certain catalytic system (a metal organiccatalyst, a chiral reagent and water) according to a certain ratio and according to a certain sequence to obtain the high-purity S-type chiral sulfoxide compound. According to the invention, the reaction conditions are mild, the high-purity S-type chiral sulfoxide compound can be obtained with high yield under the optimal conditions, and the subsequent research on the biological activity of the S-type chiral sulfoxide compound is facilitated.

A process for the preparation of substances related to for standard auspicious Luo river , detection method and use (by machine translation)

This invention offers for standard auspicious Luo river oxide (1S, 2S, 3R, 5S)-3-[ 7-{ [(1R, 2S)-2-(3.4-difluorophenyl) cyclopropyl] amino}-5-(propyl-sulfinyl)-3H-[ 1, 2, 3] triazolo-[ 4, 5-d] pyrimidin-3-yl]-5-(2-hydroxy-ethoxy) cyclopentane -1, 2-diol a