376608-75-2Relevant articles and documents
NEW USE OF TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES
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Page/Page column 13; 16, (2021/01/29)
Triazolo[4,5-d]pyrimidine derivatives of formula (I) for use in prognosis and/or diagnosis of bacterial infection in a host mammal and method of imaging thereof. Formula (I) wherein R1 is C3-5 alkyl optionally substituted by one or m
PROCESS FOR THE PREPARATION OF TICAGRELOR
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Page/Page column 11-12, (2021/12/28)
The present invention relates to a process for the preparation of ticagrelor, which provides a product of high purity, in particular, with no detectable levels of Nnitrosmine impurities. The process comprises a first step of treating 2- [[(3aR,4S,6R,6aS)-6-[[5-amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol starting material with sodium nitrite, followed by acidic washing; in a second step, the 2-[[(3aR,4S,6R,6aS)-6-[7-chloro-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H- cyclopenta-1,3-dioxol-4-yl]oxy]ethanol obtained in the previous step is coupled with trans-(1 fl,2S)-2-(3,4-difluorophenyl)cyclopropylamine, and the reaction is followed by a first washing at basic pH a second washing at acidic pH; and in an third step, the compound obtained in the previous step is deprotected by treatment with mineral acid, followed by acidic washing.
S-type chiral sulfoxide compound preparation method
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Paragraph 0048-0051, (2020/02/10)
The invention belongs to the field of chemical synthesis, and particularly relates to an S-type chiral sulfoxide compound preparation method, which mainly comprises four steps of cyclization, substitution, catalytic oxidation and hydrolysis removal of isopropylidene, wherein a catalytic oxidation reaction is carried out by adopting a certain catalyst and a certain catalytic system (a metal organiccatalyst, a chiral reagent and water) according to a certain ratio and according to a certain sequence to obtain the high-purity S-type chiral sulfoxide compound. According to the invention, the reaction conditions are mild, the high-purity S-type chiral sulfoxide compound can be obtained with high yield under the optimal conditions, and the subsequent research on the biological activity of the S-type chiral sulfoxide compound is facilitated.