16473-35-1Relevant articles and documents
Catalytic Asymmetric Disulfuration by a Chiral Bulky Three-Component Lewis Acid-Base
Zhang, Qi,Li, Yao,Zhang, Long,Luo, Sanzhong
, p. 10971 - 10976 (2021)
A three-component Lewis acid–base (Lewis trio) involving a bulky chiral primary amine, B(C6F5)3 and a bulky tertiary amine has been developed as an effective enamine catalyst for enantioselective disulfuration reactions. The bulky tertiary amine was found to activate a bulky primary–tertiary diamine–borane Lewis pair for enamine catalysis via frustrated interaction. The resulted chiral bulky Lewis trio (BLT) allows for the construction of chiral disulfides via direct disulfuration with β-ketocarbonyls or α-branched aldehydes in a practical and highly stereocontrolled manner.
Rapid assembly of phosphate-bridged tetra-mannose by ionic liquid-supported oligosaccharide synthesis
Yang, Guangyi,Mei, Guodong,Shen, Peng,Hong, Haofei,Wu, Zhimeng
, (2020/12/02)
An efficient ionic liquid-supported oligosaccharide synthesis (ILSOS) strategy was described for the synthesis of linear oligo-phosphomannan. A new cleavable benzyl carbamate-type IL supporter containing 5-aminopentanyl linker was designed as an acceptor IL tag to facilitate this synthesis. The chain elongation on IL tag was achieved by H-phosphonate chemistry, including condensation with α-mannosyl H-phosphonate, in situ oxidation reaction and subsequent deprotection. After four cycles, linear α-(1 → 6)-tetra-mannan phosphate was obtained with a total yield of 52.7% within 45 h. The IL tagged product exhibited a tunable solubility in polar and non-polar solvent systems that facilitate a chromatography-free purification in the assembly process. The IL tag could be easily removed after hydrogenolysis treatment after the final step, to afford an amine terminated linker at the reducing end of phosphoglycan for further conjugation with a carrier protein. This methodology offered an efficient and chromatography-free approach for the synthesis of phosphoglycan.
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Paragraph 0070, (2018/01/02)
PROBLEM TO BE SOLVED: To provide a dibenzyl trithiocarbonate derivative having various functional groups at both terminals of the molecule and to provide a method for producing the same.SOLUTION: There is provided a dibenzyl trithiocarbonate derivative represented by the following general formula (1): wherein, Ar is a phenylene group or a naphthylene group; R is an acetoxy group, a hydroxy group, a hydroxymethyl group, or a methoxycarbonyl group having a substituent represented by the formula, -C(O)-O-CH-R(wherein, Ris a Cto Calkyl or a Cto Calkenyl group having a substituent). There is provided a method for producing a dibenzyl trithiocarbonate derivative represented by the general formula (1) in which a compound represented by the formula (3) (wherein X is a halogen atom) is reacted with a trithiocarbonate in an amide-based solvent to trithiocarbonate.
