16537-05-6

Basic information

• Product Name: Cyclohexanecarboxylic acid, 1,1-diMethylethyl ester
• Synonyms: Cyclohexanecarboxylic acid, 1,1-diMethylethyl ester
• CAS NO: 16537-05-6
• Molecular Formula: C₁₁H₂₀O₂
• Molecular Weight: 184.2753
• EINECS: -0
• Mol File: 16537-05-6.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 82.5-85.5 °C(Press: 9 Torr)
• Appearance: /
• Density: 0.951±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Cyclohexanecarboxylic acid, 1,1-diMethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarboxylic acid, 1,1-diMethylethyl ester(16537-05-6)
• EPA Substance Registry System: Cyclohexanecarboxylic acid, 1,1-diMethylethyl ester(16537-05-6)

Safety Data

• Hazardous Substances Data: 16537-05-6(Hazardous Substances Data)

Upstream product

• 66823-00-5 2-cyclohexyl-2-methoxy-[1,3]dioxolane 
• 58587-03-4 S-phenyl cyclohexanecarbothioate 
• 75-65-0 tert-butyl alcohol 
• 115-11-7 isobutene 
• 98-89-5 Cyclohexanecarboxylic acid 
• 89611-19-8 Cyclohexanecarboxylic acid (Z)-2-dimethylcarbamoyl-1-methyl-vinyl ester 
• 68557-32-4 cyclohexanecarboxylic acid N'-phenylhydrazide 
• 1907-33-1 lithium tert-butoxide 
• 5814-04-0 1,2-bis-(cyclohexanecarbonyl)hydrazine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 865-47-4 potassium tert-butylate 
• 100-49-2 cyclohexylmethyl alcohol 
• 141-53-7 sodium formate 

Downstream Products

• 60774-55-2 2-Methylthiocyclohexancarbonsaeure-tert.-butylester 
• 85738-90-5 3-chloro-2-(1-t-butoxycarbonylcyclohexyl)-1,4-naphthoquinone 
• 22173-21-3 tert-butyl cyclohex-1-ene-1-carboxylate 
• 1001379-51-6 1-allylcyclohexanecarboxylic acid tert-butyl ester 
• 158414-45-0 (1S,2R)-2-aminocyclohexanecarboxylic acid hydrochloride 
• 158414-45-0 (1S,2S)-(+)-2-aminocyclohexane-1-carboxylic acid hydrochloride 
• 158414-45-0 (R,R)-trans-2-aminocyclohexanecarboxylic acid hydrochloride 
• 158414-45-0 (-)-(1R,2S)-2-aminocyclohexanecarboxylic acid hydrochloride 
• 151294-67-6 (1S,2R)-2-[Benzyl-((R)-1-phenyl-ethyl)-amino]-cyclohexanecarboxylic acid tert-butyl ester 
• 151379-88-3 tert-butyl (1R,2R,αR)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate 
• 158414-49-4 tert-butyl (1S,2S,αS)-2-(N-benzyl-N-α-methylbenzylamino)cyclohexane-1-carboxylate 
• 158414-47-2 (1R,2S,αS)-tert-butyl 2-(N-benzyl-N-α-methylbenzylamino)cyclohexanecarboxylate 
• 85750-74-9 2-(1-carboxycyclohexyl)-3-hydroxy-1,4-naphthoquinone 
• 85738-93-8 2-(1-carboxycyclohexyl)-3-chloro-1,4-naphthoquinone 

Relevant articles and documents

A fast and practical synthesis of tert-butyl esters from 2-tert-butoxypyridine using boron trifluoride·diethyl etherate under mild conditions

A practical direct preparation of tert-butyl esters from 2-tert-butoxypyridine has been developed. This system features the use of boron trifluoride·diethyl etherate in toluene solvent to rapidly achieve the reaction at room temperature. Using this reaction protocol, a variety of tert-butyl esters were synthesized from several different carboxylic acids at high yields. This practical procedure provides a promising and effective approach to the protection of carboxylic acids with a tert-butyl group.

Intramolecular rearrangement of α-azidoperoxides: An efficient synthesis of tert-butyl esters

An unprecedented intramolecular rearrangement of α-azidoperoxides, promoted by simple organic base to provide tert-butyl esters, has been presented. Further, a one-pot methodology consisting of in situ generation of the α-azidoperoxides from corresponding aldehydes followed by base-promoted rearrangement to obtain the desired ester has also been executed. Relevant mechanistic studies, to provide the proof for intramolecular alkoxy transfer, are investigated.

Hydroesterification of alkenes with sodium formate and alcohols promoted by cooperative catalysis of Ru3(CO)12 and 2-pyridinemethanol

(Figure Presented) A chelation-assisted hydroesterification reaction of alkenes with sodium formate and alcohols that involves cooperative catalysis by Ru3(CO)12 and 2-pyridinemethanol is described. In this three-component coupling reaction, sodium formate serves as the carbon monoxide source.