1907-33-1 Usage
Description
Lithium tert-butoxide is an organometallic compound with the chemical formula LiOtBu, where OtBu represents a tert-butoxide anion. It is a white crystalline solid and is known for its strong basic properties. As a mild base, it is widely used in various organic synthesis reactions due to its ability to selectively deprotonate a wide range of substrates without causing unwanted side reactions.
Uses
1. Used in Organic Synthesis:
Lithium tert-butoxide is used as a mild base for various organic synthesis reactions, such as the α-alkylation of ketones with primary alcohols. Its strong basic properties allow it to selectively deprotonate substrates, facilitating the formation of new carbon-carbon bonds and enhancing the overall yield of the reaction.
2. Used as a Catalyst in the Reduction of Ketones:
In the reduction of ketones to the corresponding secondary alcohols, lithium tert-butoxide acts as an efficient catalyst. It promotes the transfer of hydride ions from a reducing agent, such as lithium aluminum hydride (LiAlH4), to the carbonyl group of the ketone, resulting in the formation of the desired secondary alcohol.
3. Used in the Preparation of LixTiyOz Thin Films:
Lithium tert-butoxide serves as a lithium source in the preparation of LixTiyOz thin films, which are essential components in various electronic devices, such as lithium-ion batteries and solid-state electrolytes. Its use in this application ensures a controlled and uniform deposition of lithium ions, leading to improved film quality and performance.
4. Used in Conjunction with Organometallic Reagents/Catalysts:
Lithium tert-butoxide is also utilized in combination with organometallic reagents and catalysts to modify their reactivity and selectivity. By acting as a ligand or a counterion, it can influence the electronic and steric properties of the organometallic species, thereby enhancing their performance in various catalytic reactions, such as cross-coupling and polymerization processes.
Biochem/physiol Actions
Enterotoxigenic Escherichia coli causes diarrhea through its heat-labile enterotoxin (LT). The LT is a periplasmic protein composed of one A subunit (LTA, 27 kDa) and five non-covalently associated B subunits (LTB, 11.6 kDa each) forming a ring-like pentamer. LTB has high affinity towards the toxin receptor ganglioside GM1, a glycosphingolipid found ubiquitously on the surface of mammalian cells. Ganglioside GM1 facilitates the delivery of the A subunit to the cytosol of the target cell resulting in persistent synthesis of cAMP and subsequently diarrhea. This characteristic makes LTB a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface). In addition, studies made mostly with animal models demonstrated that recombinant LTB could stimulate strong serum and mucosal immune responses against LT. Other studies have indicated that LTB could be used as a potent mucosal adjuvant.
Check Digit Verification of cas no
The CAS Registry Mumber 1907-33-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,0 and 7 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1907-33:
(6*1)+(5*9)+(4*0)+(3*7)+(2*3)+(1*3)=81
81 % 10 = 1
So 1907-33-1 is a valid CAS Registry Number.
InChI:InChI=1/C4H9O.Li/c1-4(2,3)5;/h1-3H3;/q-1;+1/rC4H9LiO/c1-4(2,3)6-5/h1-3H3
1907-33-1Relevant articles and documents
Total Synthesis of (-)-N-Methylwelwitindolinone C Isothiocyanate Based on a Pd-Catalyzed Tandem Enolate Coupling Strategy
Komine, Keita,Nomura, Yusuke,Ishihara, Jun,Hatakeyama, Susumi
, p. 3918 - 3921 (2015)
The highly stereocontrolled total synthesis of (-)-N-methylwelwitindolinone C isothiocyanate is described, which features the expeditious construction of a bicyclo[4.3.1]decane ring system by a palladium-catalyzed tandem enolate allylation/arylation reaction.
IMIDE COMPLEX, METHOD FOR PRODUCING THE SAME, METAL-CONTAINING THIN FILM AND METHOD FOR PRODUCING THE SAME
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Page/Page column 9; 12; 13-14; 15-18; 19-20; 24; 25, (2009/06/27)
Objects of the present invention are to provide a novel niobium or tantalum complex having good vapor pressure and becoming a raw material for producing a niobium- or tantalum-containing thin film by a method such as CVD method, ALD method or the like, a method for producing the same, a metal-containing thin film using the same, and a method for producing the same. The present invention relates to producing an imide complex represented by the general formula (1) by, for example, the reaction between M1(NR1)X3(L)r (2) and an alkali metal alkoxide (3): (wherein M1 represents niobium atom or tantalum atom, R1 represents an alkyl group having from 1 to 12 carbon atoms, R2 represents an alkyl group having from 2 to 13 carbon atoms, X represents halogen atom, r is 1 when L is 1,2-dimethoxyethane ligand, r is 2 when L is pyridine ligand, and M2 represents an alkali metal), and producing a niobium- or tantalum-containing thin film by using the imide complex (1) as a raw material.
METHOD FOR PRODUCING AN OPTICALLY ACTIVE TETRAHYDROQUINOLINE
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Page 77, (2008/06/13)
The present invention provides an industrially advantageous production method of optically active tetrahydroquinolines of formula (1), which comprises: 1) a step of reacting a β-ketoester of formula (2) with an amine of formula (3) to produce an enaminoester of formula (4); 2) a step of subjecting the enaminoester of formula (4) above obtained in 1) to asymmetric hydrogenation to produce an optically active β-amino acid derivative of formula (5); 3) a step of amidating the optically active β-amino acid derivative (5) above obtained in 2) to produce an amide of formula (6); 4) step of alkoxycarbonylating the amide of formula (6) above obtained in 3) to produce a compound of formula (7); and 5) a step of subjecting the compound of formula (7) above to cyclization to produce the optically active tetrahydroquinoline of formula (1).