165657-63-6Relevant articles and documents
Substitutive nicotinamide compound, medicine composition and application of composition
-
Paragraph 0217; 0218; 0219; 0256; 0257; 0258, (2019/04/30)
The invention provides a substitutive nicotinamide compound, a composition containing the compound and application of the composition. The substitutive nicotinamide compound is shown in the formula (I) or pharmaceutically acceptable salt, prodrug, hydrate
FUSED BENZENE DERIVATIVE AND USE
-
Page/Page column 56, (2010/02/12)
The present invention provides a compound represented by the general formula: [wherein Ring A represents an optionally substituted 5- to 8-membered ring, Ring B represents a further optionally substituted 4- to 10-membered ring, Ring C represents a further optionally substituted benzene ring, X1 represents carbon atom, X2 represents a carbon atom, an oxygen atom, etc., W represents a nitrogen atom, etc., Y11 represents a group represented by the formula CR2R3' (wherein R2 represents a hydrogen atom, a cyano group, a nitro group, etc., and R3' represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), Y21 represents a group represented by the formula CR4R5' (wherein R4 represents a hydrogen atom, a cyano group, a nitro group, etc., and R5' represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), etc., and R1 represents an electron-withdrawing group, respectively. The formula represents a single bond or a double bond] or a salt thereof, which is useful as an androgen receptor modulator.
Practical synthesis of (R)-1-benzyl-3-hydroxy-2,5-pyrrolidinedione and its acetate from L-tartaric acid
Tomori, Hiroshi,Maruyama, Hiroshi,Ogura, Katsuyuki
, p. 415 - 423 (2007/10/03)
An efficient method for preparing (R)-1-benzyl-3-hydroxy-2,5-pyrrolidinedione and its acetate is described starting from L-tartaric acid, which affords the desired compounds with 99% ee in good overall yields (63-74%).