129823-21-8

Basic information

• Product Name: 2,5-Pyrrolidinedione,3-(acetyloxy)-1-(phenylmethyl)-, (3S)-
• Synonyms: 2,5-Pyrrolidinedione,3-(acetyloxy)-1-(phenylmethyl)-, (S)-; (S)-3-Acetoxy-N-benzyl-2,5-dioxopyrrolidine
• CAS NO: 129823-21-8
• Molecular Formula: C13H13 N O4
• Molecular Weight: 247.251
• Mol File: 129823-21-8.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 2,5-Pyrrolidinedione,3-(acetyloxy)-1-(phenylmethyl)-, (3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Pyrrolidinedione,3-(acetyloxy)-1-(phenylmethyl)-, (3S)-(129823-21-8)
• EPA Substance Registry System: 2,5-Pyrrolidinedione,3-(acetyloxy)-1-(phenylmethyl)-, (3S)-(129823-21-8)

Safety Data

• Hazardous Substances Data: 129823-21-8(Hazardous Substances Data)

Usage

Physical State

Crystalline solid

Molecular Weight

271.314 g/mol

Main Application

Intermediate in pharmaceutical synthesis

Specific Use

Production of antipsychotics and antidepressants

Additional Properties

Exhibits anti-inflammatory and analgesic properties

Industry

Valuable ingredient in pharmaceutical manufacturing

Upstream product

• 617-48-1 malic acid 
• 75-36-5 acetyl chloride 
• 100-46-9 benzylamine 
• 59025-03-5 (S)-acetoxysuccinic anhydride 
• 24766-96-9 3-acetoxy-2,5-dioxo-tetrahydrofuran 
• 2174-58-5 L-malic acid 
• 108-24-7 acetic anhydride 
• 101469-91-4 (3S)-1-benzyl-3-hydroxypyrrolidine-2,5-dione 
• 129823-21-8 3-acetoxy-1-benzyl-2,5-pyrrolidinedione 
• 85319-64-8 L-acetoxysuccinic acid 
• 97-67-6 (S)-Malic acid 
• 78027-57-3 (RS)-N-benzyl-3-hydroxypyrrolidine-2,5-dione 

Downstream Products

• 129823-21-8 (S)-4-acetoxy-1-benzyl-2,5-pyrrolidinedione 
• 165657-63-6 (3R)-1-benzyl-3-hydroxypyrrolidine-2,5-dione 
• 188295-12-7 (S)-1-Benzyl-5-ethoxy-4-hydroxy-pyrrolidin-2-one 
• 199103-42-9 Acetic acid (S)-1-benzyl-2-ethoxy-5-oxo-pyrrolidin-3-yl ester 
• 133005-21-7 acetic acid (2S,3S)-2-acetoxy-1-benzyl-5-oxo-pyrrolidin-3-yl ester 
• 199103-45-2 1-benzyl-5-ethoxy-4-hydroxy-3-(prop-2-ynyl)-2-pyrrolidinone 
• 199103-41-8 (1S,6R,9S)-7-benzyl-9-hydroxy-7-azabicyclo[4.2.1]nonane-4,8-dione 
• 199103-44-1 1-benzyl-5-ethoxy-4-hydroxy-3-(buta-2,3-dienyl)-2-pyrrolidinone 
• 199103-43-0 1-benzyl-5-ethoxy-4-hydroxy-3-(but-3-ynyl)-2-pyrrolidinone 
• 199103-48-5 (1S,6R)-7-benzyl-4,4-(ethylenedioxy)-9-methylene-7-azabicyclo[4.2.1]nonane-8-one 
• 199103-46-3 (1S,6R,9S)-7-benzyl-4,4-(ethylenedioxy)-9-hydroxy-7-azabicyclo[4.2.1]nonane-8-one 
• 199103-47-4 (1S,6R)-7-benzyl-4,4-(ethylenedioxy)-7-azabicyclo[4.2.1]nonane-8,9-dione 
• 199103-49-6 (1S,6R,9R)-7-benzyl-4,4-(ethylenedioxy)-9-(hydroxymethylene)-7-azabicyclo[4.2.1]nonane-8-one 
• 199103-51-0 (1S,6R,9R)-7-benzyl-4,4-(ethylenedioxy)-9-(methoxymethylene)-7-azabicyclo[4.2.1]nonane-8-one 

Relevant articles and documents

Lewis-acid catalyzed N-acyliminium ion cyclodimerization: Synthesis of symmetrical 1,4-dioxanes

The cyclodimerization reaction of N-substituted-5-hydroxy-pyrrolydinones promoted by BF3·Et2O and HCl to obtain symmetrical 1,4-dioxane derivatives was achieved in moderate to good yields, mild conditions, and short reaction times. These transformations render a promising alternative route that provides access to diverse 1,4-dioxane derivatives with a wide structural diversity.

COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY

Disclosed are indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which LRRK2 kinase is involved. Also disclosed are pharmaceutical compositions in the prevention or treatment of such diseases in which LRRK2 kinase is involved.

COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY

Provided are indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which LRRK2 kinase is involved. Also provided are pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK2 kinase is involved.