165669-13-6

Basic information

• Product Name: 3-CHLORO-1H-INDOL-7-AMINE
• Synonyms: 3-CHLORO-1H-INDOL-7-AMINE;1H-Indol-7-aMine, 3-chloro-
• CAS NO: 165669-13-6
• Molecular Formula: C₈H₇ClN₂
• Molecular Weight: 166.61
• Mol File: 165669-13-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-CHLORO-1H-INDOL-7-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-1H-INDOL-7-AMINE(165669-13-6)
• EPA Substance Registry System: 3-CHLORO-1H-INDOL-7-AMINE(165669-13-6)

Safety Data

• Hazardous Substances Data: 165669-13-6(Hazardous Substances Data)

Usage

General Description

3-Chloro-1H-indol-7-amine is a chemical compound with the molecular formula C8H7ClN2. It is a derivative of indole, containing a chlorine atom at the 3-position and an amino group at the 7-position. 3-CHLORO-1H-INDOL-7-AMINE is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. It is known for its potential biological and pharmacological activities, including its use in the development of anticancer and antiviral drugs. Additionally, 3-Chloro-1H-indol-7-amine has been studied for its potential as an antioxidant and radical scavenger, making it a versatile and valuable chemical in the field of medicinal chemistry.

Upstream product

• 165669-14-7 7-nitro-3-chloro-1H-indole 
• 6960-42-5 7-nitro-1H-indole 

Downstream Products

• 165668-24-6 N-(3-chloro-7-indolyl)-4-nitrobenzenesulfonamide 
• 165668-32-6 N-(3-Chloro-1H-indole-7-yl)-4-cyanobenzenesulfonamide 
• 165668-25-7 4-Amino-N-(3-chloro-1H-indole-7-yl)benzenesulfonamide 
• 165668-51-9 4-Carbamoyl-N-(3-chloro-1H-indole-7-yl)benzenesulfonamide 
• 418811-67-3 7-benzyloxy-4-(3-chloroindol-7-ylamino)-6-methoxyquinazoline 
• 945396-44-1 N'-(3-chloro-1H-indol-7-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine 

Relevant articles and documents

COMPOUNDS AND USES THEREOF

The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

Synthesis and biological evaluation of N-(7-indolyl)-3-pyridinesulfonamide derivatives as potent antitumor agents.

We herein report the synthesis and antitumor activity of E7070 analogues containing a 3-pyridinesulfonamide moiety. E7070 was selected from our sulfonamide-based compound collections, currently undergoing Phase II clinical trials because of its tolerable toxicity profile and some antitumor responses in the Phase I setting. Of the analogues examined, ER-35745, a 6-amino-3-pyridinesulfonamide derivative, demonstrated significant oral efficacy against the HCT116 human colon carcinoma xenograft in nude mice.

Lactam inhibitors of factor Xa and method

Lactam inhibitors are provided which have the structure including pharmaceutically acceptable salts thereof and all stereoisomers thereof, and prodrug esters thereof, wherein n is 1 to 5; and and R1, R2, R3, R4, R5 , R6, R7, R8, R9, R10, R10a, 1011 and R12 are as defined herein. These compounds are inhibitors of Factor Xa and thus are useful as anticoagulants. A method for treating cardiovascular diseases associated with thromboses is also provided.