6960-42-5 Usage
Description
7-Nitroindole is an organic compound that serves as a versatile reagent in chemical synthesis, particularly for the preparation of various compounds and inhibitors.
Uses
Used in Pharmaceutical Industry:
7-Nitroindole is used as a reagent for the synthesis of protein kinase inhibitors, which are important in the development of drugs targeting various diseases, including cancer and inflammatory conditions.
Used in Enzyme Inhibition:
7-Nitroindole is used as a reactant for the preparation of inosine monophosphate dehydrogenase (IMPDH) inhibitors, which play a role in the regulation of purine biosynthesis and have potential applications in the treatment of autoimmune diseases and cancer.
Used in Metabolic Regulation:
7-Nitroindole is used as a reactant for the preparation of potential fructose 1,6-bisphosphatase inhibitors, which can help regulate glucose metabolism and may have implications in the treatment of diabetes and other metabolic disorders.
Used in Blood Coagulation:
7-Nitroindole is used as a reactant for the preparation of factor Xa inhibitors, which are involved in the blood coagulation process and can be used in the development of anticoagulant drugs.
Used in Hormone Regulation:
7-Nitroindole is used as a reactant for the preparation of antagonists of the mineralocorticoid receptor, which can help regulate hormone levels and may be useful in the treatment of hypertension and other hormone-related disorders.
Used in Antitumor Therapy:
7-Nitroindole is used as a reactant for the preparation of antitumor sulfonamides, which have potential applications in cancer treatment by inhibiting the growth of tumor cells.
Used in Inflammation Management:
7-Nitroindole is used as a reactant for the preparation of subtype-selective cyclooxygenase (COX) inhibitors, which can help manage inflammation and pain by targeting specific COX enzymes.
Used in Thrombin Receptor Modulation:
7-Nitroindole is used as a reactant for the preparation of thrombin protease-activated receptor (PAR-1) ligands, which can modulate the activity of thrombin receptors and have potential applications in the treatment of thrombotic and inflammatory disorders.
Used in Photochemistry:
7-Nitroindole has also been used as a photochemical precursor of the 2'-deoxyribonucleotide analog, which can be utilized in the synthesis of nucleic acid analogs and has potential applications in the development of antiviral and anticancer drugs.
Synthesis Reference(s)
Canadian Journal of Chemistry, 42, p. 1235, 1964 DOI: 10.1139/v64-189
Check Digit Verification of cas no
The CAS Registry Mumber 6960-42-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,9,6 and 0 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 6960-42:
(6*6)+(5*9)+(4*6)+(3*0)+(2*4)+(1*2)=115
115 % 10 = 5
So 6960-42-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H6N2O2/c11-10(12)7-3-1-2-6-4-5-9-8(6)7/h1-5,9H
6960-42-5Relevant articles and documents
Method for catalytically synthesizing indole derivative by using ferrous complex
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Paragraph 0049-0052, (2021/07/31)
The invention relates to a method for catalytically synthesizing an indole derivative by using a ferrous complex, which comprises the following step: by taking arylamine and acetaldehyde as raw materials and a ferrous complex containing a meta-carboboryl methylpyridine structure as a catalyst, conducting reacting at room temperature to prepare the indole derivative. Compared with the prior art, the method utilizes the ferrous complex to efficiently catalyze the reaction of arylamine and acetaldehyde at room temperature to prepare the indole derivative, the reaction condition is mild, the substrate range is wide, and the method has high catalytic activity and yield.
Method for synthesizing 7-nitroindole
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Paragraph 0010; 0020; 0022; 0023-0025, (2020/03/09)
The invention relates to a method for synthesizing 7-nitroindole. The method comprises the following steps: subjecting oxime generated by condensation of o-nitroaniline, hydroxylamine and chloral to anucleophilic substitution reaction in a solvent under the action of an acidic substance and a drying agent, and performing hydrolyzing under alkaline conditions to generate an oximido intermediate; preparing 7-nitroisatin from the oximido intermediate in the presence of an acidic substance; and subjecting the 7-nitroisatin to reduction in a solvent by a system consisting of sodium borohydride andzirconium chloride so as to obtain the product 7-nitroindole. According to the method for synthesizing the 7-nitroindole, the product is obtained through three steps, so a production cycle is remarkably shortened and productivity is improved; used materials are simple and easily-available, so cost is low; reaction conditions are mild; the method is suitable for industrial mass production; meanwhile, the system of sodium borohydride and zirconium tetrachloride is used for replacing borane in the reduction step, so virulent, flammable and combustible raw materials are avoided, and the method issafer and environmentally friendlier.
Sweet anion receptors: Recognition of chiral carboxylate anions by d-glucuronic-acid-decorated diindolylmethane
Granda, Jaroslaw M.,Jurczak, Janusz
supporting information, p. 4730 - 4733 (2013/10/08)
Anion receptors containing glucuronic acid were synthesized, and their anion binding ability studied. Chirality of anionic guests derived from mandelic acid and amino acids can be distinguished not only in terms of stability constants but also by signific
