16659-88-4 Usage
Description
(+/-)-TETRAHYDROPAPAVEROLINE HYDROBROMIDE, also known as Norlaudanosoline, is a key intermediate on the biosynthetic pathway to morphinan and benzylisoquinoline alkaloids. It is a white to grey crystalline powder with unique chemical properties that make it valuable in various applications.
Uses
Used in Pharmaceutical Industry:
(+/-)-TETRAHYDROPAPAVEROLINE HYDROBROMIDE is used as a key intermediate for the synthesis of various pharmaceutical compounds, particularly morphinan and benzylisoquinoline alkaloids. Its role in the biosynthetic pathway allows for the development of new drugs and therapeutic agents.
Used in Chemical Research:
(+/-)-TETRAHYDROPAPAVEROLINE HYDROBROMIDE is used as a research compound in the field of chemistry, particularly for studying the synthesis and properties of morphinan and benzylisoquinoline alkaloids. Its unique chemical properties make it a valuable tool for understanding the structure and function of these complex molecules.
Used in Drug Development:
(+/-)-TETRAHYDROPAPAVEROLINE HYDROBROMIDE is used as a starting material in the development of new drugs and pharmaceuticals. Its presence in the biosynthetic pathway of morphinan and benzylisoquinoline alkaloids makes it a crucial component in the creation of novel therapeutic agents with potential applications in various medical fields.
Check Digit Verification of cas no
The CAS Registry Mumber 16659-88-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,6,5 and 9 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 16659-88:
(7*1)+(6*6)+(5*6)+(4*5)+(3*9)+(2*8)+(1*8)=144
144 % 10 = 4
So 16659-88-4 is a valid CAS Registry Number.
InChI:InChI=1/C16H17NO4/c18-13-2-1-9(6-14(13)19)5-12-11-8-16(21)15(20)7-10(11)3-4-17-12/h1-2,6-8,12,17-21H,3-5H2/p+1/t12-/m1/s1
16659-88-4Relevant articles and documents
Geranyl derivatives of isoquinoline alkaloids show increased biological activities
Nishiyama, Yumi,Iwasa, Kinuko,Okada, Suguru,Takeuchi, Sousuke,Moriyasu, Masataka,Kamigauchi, Miyoko,Koyama, Junko,Takeuchi, Atsuko,Tokuda, Harukuni,Kim, Hye-Sook,Wataya, Yusuke,Takeda, Kazuyoshi,Liu, Yi-Nan,Wu, Pei-Chi,Bastow, Kenneth F.,Akiyama, Toshiyuki,Lee, Kuo-Hsiung
experimental part, p. 1193 - 1229 (2011/04/16)
Three types of isoquinoline alkaloids were tested for antimicrobial, cytotoxic, anti-malarial, anti-oxidant, and anti-HIV activities, as well as inhibitory activity against Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. N-or O-Geranylation contributed to increased potency in four types of activities except anti-HIV and anti-oxidant. Some types of alkaloids may be useful as lead compounds for developing potential chemotherapeutic agents. N,N-Geranylated salsolinol was significantly active in three different assays, antimicrobial, cytotoxic, and EBV-EA, and may be a most useful compound. The Japan Institute of Heterocyclic Chemistry.
