21411-19-8

Basic information

• Product Name: N-(4-Hydroxy-3-Methoxyphenethyl)-2-(3-hydroxy-4-Methoxyphenyl)acetaMide
• Synonyms: N-(4-Hydroxy-3-Methoxyphenethyl)-2-(3-hydroxy-4-Methoxyphenyl)acetaMide
• CAS NO: 21411-19-8
• Molecular Formula: C₁₈H₂₁NO₅
• Molecular Weight: 331.36304
• Product Categories: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 21411-19-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 124-126 °C
• Boiling Point: 617.1±55.0 °C(Predicted)
• Appearance: /
• Density: 1.242±0.06 g/cm3(Predicted)
• Solubility: Dimethylformamide, Methanol
• PKA: 9.79±0.10(Predicted)
• CAS DataBase Reference: N-(4-Hydroxy-3-Methoxyphenethyl)-2-(3-hydroxy-4-Methoxyphenyl)acetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Hydroxy-3-Methoxyphenethyl)-2-(3-hydroxy-4-Methoxyphenyl)acetaMide(21411-19-8)
• EPA Substance Registry System: N-(4-Hydroxy-3-Methoxyphenethyl)-2-(3-hydroxy-4-Methoxyphenyl)acetaMide(21411-19-8)

Safety Data

• Hazardous Substances Data: 21411-19-8(Hazardous Substances Data)

Usage

Description

N-(4-Hydroxy-3-Methoxyphenethyl)-2-(3-hydroxy-4-Methoxyphenyl)acetamide is a complex organic compound with a unique molecular structure. It is characterized by the presence of hydroxy and methoxy groups attached to phenethyl and phenyl moieties, which are connected through an amide linkage. This off-white solid is known for its potential applications in the synthesis of various bioactive compounds.

Uses

Used in Pharmaceutical Industry:
N-(4-Hydroxy-3-Methoxyphenethyl)-2-(3-hydroxy-4-Methoxyphenyl)acetamide is used as a key intermediate in the preparation of polyphenolic tetrahydroisoquinoline alkaloids. These alkaloids possess a wide range of pharmacological properties, making them valuable for the development of new drugs.
Used in Allergy Treatment:
N-(4-Hydroxy-3-Methoxyphenethyl)-2-(3-hydroxy-4-Methoxyphenyl)acetamide is used as a precursor for the synthesis of N-norreticuline and its derivatives, as well as phellodendrine analogs. These compounds have been found to exhibit allergy-inhibiting properties, making them potential candidates for the development of novel allergy treatments.

Upstream product

• 1131-94-8 homoisovanillic acid 
• 554-52-9 3-Methoxytyramine 
• 4468-59-1 4-hydroxy-3-methoxyphenylacetonitrile 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 53172-30-8 [1-(3-Benzyloxy-4-methoxy-phenyl)-meth-(E)-ylidene]-phenyl-amine 
• 71146-43-5 Acetic acid 1-(4-benzyloxy-3-methoxy-phenyl)-2-isocyano-ethyl ester 
• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 

Downstream Products

• 72258-91-4 1,2-dehydronorreticuline 
• 13168-51-9 N-benzoyl-norreticuline 
• 58116-06-6 (+/-)-6'-Bromo-N-norreticuline 
• 14199-16-7 (+)-Reticuline-Perchloric Acid 
• 72258-95-8 (+/-)-6'-Bromotetrahydropapaveroline-Hydrogen Bromide 
• 72258-89-0 (-)-Reticuline-Perchloric Acid 
• 72274-69-2 (+)-N-Formyl-N-norreticuline 
• 72274-70-5 (-)-N-Formyl-N-norreticuline 
• 16659-88-4 (+/-)-Tetrahydropapaveroline hydrobromide 
• 6507-35-3 (R)-1-(3-Hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride 
• 6451-82-7 (-)-Norreticuline hydrochloride 

Relevant articles and documents

Expedient synthesis of racemic and optically active N-norreticuline and N-substituted and 6'-bromo-N-norreticulines

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