167215-77-2

Basic information

• Product Name: Benzoic acid, 4-[[(methylsulfonyl)oxy]methyl]-, methyl ester
• CAS NO: 167215-77-2
• Molecular Formula: C10H12O5S
• Molecular Weight: 244.268
• Mol File: 167215-77-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[[(methylsulfonyl)oxy]methyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[[(methylsulfonyl)oxy]methyl]-, methyl ester(167215-77-2)
• EPA Substance Registry System: Benzoic acid, 4-[[(methylsulfonyl)oxy]methyl]-, methyl ester(167215-77-2)

Safety Data

• Hazardous Substances Data: 167215-77-2(Hazardous Substances Data)

Upstream product

• 6908-41-4 4-(methoxycarbonyl)benzyl alcohol 
• 124-63-0 methanesulfonyl chloride 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 1001-62-3 bis(methanesulfonyl)peroxide 

Downstream Products

• 162554-06-5 methyl 4-(4-cyanobenzyl)benzoate 
• 23450-30-8 methyl 4-benzylbenzoate 
• 905818-70-4 methyl 4-{[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]methyl}benzoate 
• 908288-87-9 C₂₅H₃₁NO₃ 
• 167215-80-7 N-[4-(Carboxy)benzyl]-N,N'-bis[(2-triphenylmethyl-thio)ethyl]glycinamide N-hydroxysuccinimide ester 
• 167215-79-4 N-[4-(Carboxy)benzyl]-N,N'-bis[(2-triphenylmethylthio)ethyl]glycinamide 
• 1571-08-0 methyl 4-formylbenzoate 
• 6908-41-4 4-(methoxycarbonyl)benzyl alcohol 
• 167215-78-3 N-[4-(carbomethoxy)benzyl]-N,N'-bis[(2-triphenylmethylthio)ethyl]glycinamide 

Relevant articles and documents

Synthesis of Benzylic Alcohols by C-H Oxidation

Selective methylene C-H oxidation for the synthesis of alcohols with a broad scope and functional group tolerance is challenging due to the high proclivity for further oxidation of alcohols to ketones. Here, we report the selective synthesis of benzylic alcohols employing bis(methanesulfonyl) peroxide as an oxidant. We attempt to provide a rationale for the selectivity for monooxygenation, which is distinct from previous work; a proton-coupled electron transfer mechanism (PCET) may account for the difference in reactivity. We envision that our method will be useful for applications in the discovery of drugs and agrochemicals.

Coupling of arylboronic acids with benzyl halides or mesylates without adding transition metal catalysts

We report herein a transition-metal-free coupling reaction of arylboronic acids with benzyl halides and mesylates for the construction of C(sp2)[sbnd]C(sp3) bonds. A unique feature of this coupling reaction is the formation regioisomers in some cases. Mechanistic studies suggest that this reaction may proceed via an unprecedented Friedel–Crafts-type reaction pathway under base conditions with the assistance of boronic acid moiety.

BENZAZOLE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention is directed to benzazole compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated wi