16727-43-8 Usage
Description
2,6-Dimethoxypyridine-3-carboxylic acid (2,6-Dimethoxynicotinic acid, DMPH) is a piperidine derivative known for its ability to form various organotin(IV) complexes. It is characterized by its potential applications in the synthesis of novel benzothiazolo naphthyridone carboxylic acid derivatives and its antiproliferative action against certain types of cancer.
Uses
Used in Pharmaceutical Industry:
2,6-Dimethoxypyridine-3-carboxylic acid is used as a key intermediate in the preparation of novel benzothiazolo naphthyridone carboxylic acid derivatives, which are significant for their potential pharmaceutical applications.
Used in Chemical Synthesis:
2,6-Dimethoxypyridine-3-carboxylic acid is used as a reactant for the preparation of various organotin(IV) complexes via reaction with different precursors such as [Ti(η5-C5H5)2Cl2], [Ti(η5-C5H4Me)2Cl2], [Ti(η5-C5H4SiMe3)(η5-C5H5)Cl2], [Ti(η5-C5Me5)Cl3], SnMe3Cl, and GatBu3. These complexes are valuable in the field of chemical synthesis and materials science.
Used in Anticancer Applications:
2,6-Dimethoxypyridine-3-carboxylic acid is used as a compound with antiproliferative properties for its action against pancreatic carcinoma (PANC-1), erythroleukemia (K562), and two glioblastoma multiform (U87 and LN-229) human cell lines, making it a promising candidate for cancer research and treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 16727-43-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,7,2 and 7 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 16727-43:
(7*1)+(6*6)+(5*7)+(4*2)+(3*7)+(2*4)+(1*3)=118
118 % 10 = 8
So 16727-43-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO4/c1-12-6-4-3-5(8(10)11)7(9-6)13-2/h3-4H,1-2H3,(H,10,11)
16727-43-8Relevant articles and documents
First synthesis of methyl 2-amino-6-methoxynicotinate using a combination of microwave and flow reaction technologies
Jeges, Gyorgy,Meszaros, Tamas,Szommer, Tamas,Kovacs, Jozsef,Nagy, Tamas,Tymoshenko, Dmytro,Fotouhi, Nader,Gillespie, Paul,Kowalczyk, Agnieszka,Goodnow Jr., Robert A.
supporting information; experimental part, p. 203 - 206 (2011/03/22)
The synthesis of methyl 2-amino-6-methoxynicotinate, a valuable building block for the preparation of fused 2-pyridones, is reported. The optimized synthesis includes sequential microwave-induced regioselective 6-methoxylation, esterification, followed by microwave-induced reaction with p- methoxybenzylamine, and final deprotection under flow reaction hydrogenation conditions. Two key steps in the reported synthesis are a microwave-induced methoxylation and a microfluidic hydrogenation that afford improved regioselectivity and purity profile of the reaction products. Georg Thieme Verlag Stuttgart.