167308-39-6

Basic information

• Product Name: ethyltrimethylsilyl-2,2-difluoroketene acetal
• Synonyms: ethyltrimethylsilyl-2,2-difluoroketene acetal
• CAS NO: 167308-39-6
• Molecular Weight: 196.269
• Mol File: 167308-39-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyltrimethylsilyl-2,2-difluoroketene acetal(CAS DataBase Reference)
• NIST Chemistry Reference: ethyltrimethylsilyl-2,2-difluoroketene acetal(167308-39-6)
• EPA Substance Registry System: ethyltrimethylsilyl-2,2-difluoroketene acetal(167308-39-6)

Safety Data

• Hazardous Substances Data: 167308-39-6(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 383-63-1 ethyl trifluoroacetate, 

Downstream Products

• 114701-62-1 ethyl 2,2-difluoro-3-oxo-3-phenylpropanoate 
• 118460-52-9 ethyl 2,2-difluoro-3-oxo-5-phenylpentanoate 
• 118460-50-7 ethyl 3-cyclohexyl-2,2-difluoro-3-oxopropanoate 
• 92207-60-8 ethyl 2,2-difluoro-3-hydroxy-3-phenylpropanoate 

Relevant articles and documents

Electroreductive defluorination of trifluoromethyl ketones and trifluoroacetic acid derivatives

Difluoroenol silyl ethers 5 and 6, difluoroketene silyl (O,O-, O,S-, and O,N-) acetals 9 and 21, and 2,2-difluoro-2-trimethylsilylacetates 10 were prepared by electroreductive defluorination of trifluoromethyl ketones and trifluoroacetic acid derivatives in an MeCN-TBAB-chlorotrialkylsilane system using a carbon rod as an anode and a lead plate as a cathode. TBAF- or KF- CuI-promoted α-alkylation of 10 with electrophiles such as aldehydes, ketones, imine, acylhalides, and alkylhalides provided α-alkylated-α,α- difluoroacetates in good to excellent yields.