167642-19-5Relevant articles and documents
Selectivity of Daucus carota roots and baker's yeast in the enantioselective reduction of γ-nitroketones
Scarpi, Dina,Occhiato, Ernesto G.,Guarna, Antonio
, p. 1479 - 1483 (2007/10/03)
The enantioselective reduction of a series of aromatic γ-nitroketones was achieved by using Daucus carota roots in water, which afforded the corresponding (S)-alcohols with ees ranging from 73% to 100%. A comparison of these results with the data obtained by reducing the same substrates with baker's yeast resulted in D. carota always being more enantioselective than baker's yeast, although a lower number of substrates were reduced. The possible influence of the aromatic ring substituents on the reaction outcome is also discussed.
Microbial biotransformations in water/organic solvent system. Enantioselective reduction of aromatic β- and γ-nitroketones
Molinari, Francesco,Occhiato, Ernesto G.,Aragozzini, Fabrizio,Guarna, Antonio
, p. 1389 - 1394 (2007/10/03)
The production of single enantiomers of γ and β-nitroalcohols by microbial bioreduction has been studied. A restricted screening among 14 yeasts was performed using 1-phenyl-4-nitro-1-butanone 1 as substrate. Pichia minuta (CBS 1708) and Pichia etchellsii
Baker's yeast reduction of prochiral γ-nitroketones: Enantioselective synthesis of (S)-4-nitroalcohols
Guarna, Antonio,Occhiato, Ernesto G.,Spinetti, Laura M.,Vallecchi, Maria E.,Scarpi, Dina
, p. 1775 - 1788 (2007/10/02)
The baker's yeast reduction of seven different prochiral nitroketones 1a-g occurred on the re face of the carbonyl group, thus affording the (S)-nitroalcohols 2a-g, with different level of enantioselectivity (e.e. 15-99%). The best results (e.e. = 99%) we
