169673-92-1

Basic information

• Product Name: 7-chloro-6-fluoro-1H-indole
• Synonyms: 1H-indole, 7-chloro-6-fluoro-; 7-Chloro-6-fluoro-1H-indole
• CAS NO: 169673-92-1
• Molecular Formula: C₈H₅ClFN
• Molecular Weight: 169.5834
• Mol File: 169673-92-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 299.8°C at 760 mmHg
• Flash Point: 135.1°C
• Density: 1.436g/cm³
• Vapor Pressure: 0.00208mmHg at 25°C
• Refractive Index: 1.657
• CAS DataBase Reference: 7-chloro-6-fluoro-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-6-fluoro-1H-indole(169673-92-1)
• EPA Substance Registry System: 7-chloro-6-fluoro-1H-indole(169673-92-1)

Safety Data

• Hazardous Substances Data: 169673-92-1(Hazardous Substances Data)

Upstream product

• 169674-53-7 methyl α-azido-3-chloro-4-fluorocinnamate 
• 21397-07-9 2-chloro-3-fluoro-nitrobenzene 
• 1826-67-1 vinyl magnesium bromide 

Relevant articles and documents

(AZA)INDOLE-, BENZOTHIOPHENE-, AND BENZOFURAN-3-SULFONAMIDES

Disclosed are sulfonamide compounds with GPR17 modulating properties, which are useful for treating or preventing a variety of CNS and other diseases, in particular for preventing and treating myelinating diseases or disorders.

A novel synthesis of EGFR-tyrosine-kinase inhibitors with 4-(indol-3-yl)quinazoline structure

(Chemical Equation Presented) The epidermal growth factor (EGF) family of membrane receptors has been identified as a key element in the complex signaling network that is utilized by various classes of cell-surface receptors. A new synthetic pathway of 4-(indol-3-yl)quinazolines 15 and 16 is described using cross coupling reactions with quinazoline- and indole moieties. The synthesized compound 15 is a new dual and high potent EGFR- and HER-2-tyrosine kinase inhibitor with excellent cytotoxic properties at different cell lines. Furthermore this substance class shows remarkably strong fluorescence.