21397-07-9

Basic information

• Product Name: 2-Chloro-3-fluoronitrobenzene
• Synonyms: 1-CHLORO-2-FLUORO-6-NITRO-BENZENE;2-CHLORO-3-FLUORONITROBENZENE;2-CHLORO-1-FLUORO-3-NITRO-BENZENE;1-Nitro-2-chloro-3-fluorobenzene;Benzene, 2-chloro-1-fluoro-3-nitro-
• CAS NO: 21397-07-9
• Molecular Formula: C₆H₃ClFNO₂
• Molecular Weight: 175.54
• EINECS: 244-365-6
• Product Categories: Multisubstituted Benzene;Aromatic Halides (substituted);Benzenes
• Mol File: 21397-07-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 243.3°C at 760 mmHg
• Flash Point: 101 °C
• Appearance: /
• Density: 1.494 g/cm³
• Vapor Pressure: 0.0503mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Chloro-3-fluoronitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-fluoronitrobenzene(21397-07-9)
• EPA Substance Registry System: 2-Chloro-3-fluoronitrobenzene(21397-07-9)

Safety Data

• Hazard Codes: T
• Hazardous Substances Data: 21397-07-9(Hazardous Substances Data)

Usage

General Description

2-Chloro-3-fluoronitrobenzene is a chemical compound with the molecular formula C6H3ClFNO2. It is a nitro derivative of benzene with chlorine and fluorine substituents. 2-Chloro-3-fluoronitrobenzene is used as a building block in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It is also used in the manufacturing of dyes, pigments, and other chemical intermediates. 2-Chloro-3-fluoronitrobenzene is a yellow crystalline solid that is slightly soluble in water and has a melting point of around 42-44°C. It is important to handle this chemical with care, as it is toxic and may cause skin and eye irritation upon contact.

InChI:InChI=1/C6H3ClFNO2/c7-6-4(8)2-1-3-5(6)9(10)11/h1-3H

Upstream product

• 602-03-9 2,3-dinitroaniline 
• 17809-36-8 2-fluoro-6-nitroaniline 
• 399-31-5 N-(2-fluorophenyl)acetamide 
• 342-52-9 N-(2-fluoro-6-nitrophenyl)acetamide 
• 402-67-5 3-fluoro-1-nitrobenzene 
• 611-06-3 2,4-dichloronitrobenzene 

Downstream Products

• 21397-08-0 2-chloro-3-fluoroaniline 
• 1234010-04-8 C₁₀H₁₂FN₃O₂ 
• 1247021-61-9 [(2-fluoro-6-nitrophenyl)sulfanyl]acetic acid 
• 169673-92-1 7-chloro-6-fluoroindole 
• 17809-36-8 2-fluoro-6-nitroaniline 

Relevant articles and documents

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Design, synthesis and herbicidal activity study of aryl 2,6-disubstituted sulfonylureas as potent acetohydroxyacid synthase inhibitors

A series of sulfonylurea derivatives containing a 2,6-disubstituted aryl moiety were designed, synthesized and evaluated for their herbicidal activities. Most of these compounds showed excellent inhibitory rates against both monocotyledonous and dicotyledonous weeds, especially 10a, 10h and 10i. They exhibited equivalent or superior herbicidal efficiency than commercial chlorsulfuron at the dosage of 15?g/ha and the preliminary SAR was summarized. In order to illuminate the molecular mechanism of several potent compounds, their apparent inhibition constant (Kiapp) of Arabidopsis thaliana acetohydroxyacid synthase (AHAS) were determined and the results confirmed that these compounds were all potent AHAS inhibitors. 10i have a Kiapp of 11.5?nM, which is about 4 times as potent as chlorsulfuron (52.4?nM).

Hydroxy diphenyl urea sulfonamides as IL-8 receptor antagonists

Novell IL-8 compounds and methods of using them are provided.