169956-61-0

Basic information

• Product Name: 2-(cyclohexyloxy)-1H-isoindole-1,3(2H)-dione
• Synonyms: 2-(cyclohexyloxy)-1H-isoindole-1,3(2H)-dione
• CAS NO: 169956-61-0
• Molecular Weight: 245.278
• Mol File: 169956-61-0.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 2-(cyclohexyloxy)-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(cyclohexyloxy)-1H-isoindole-1,3(2H)-dione(169956-61-0)
• EPA Substance Registry System: 2-(cyclohexyloxy)-1H-isoindole-1,3(2H)-dione(169956-61-0)

Safety Data

• Hazardous Substances Data: 169956-61-0(Hazardous Substances Data)

Upstream product

• 524-38-9 N-hydroxyphthalimide 
• 110-82-7 cyclohexane 
• 76029-42-0 2-(cyclohex-2-en-1-yloxy)isoindoline-1,3-dione 
• 1521-51-3 rac-3-bromocyclohexene 
• 953-91-3 cyclohexyl tosylate 
• 870-50-8 di-tert-butyl (E)-azodicarboxylate 
• 108-85-0 1-bromocyclohexane 
• 108-93-0 cyclohexanol 

Downstream Products

• 1170234-85-1 7-(2-cyano-1-(pyridin-4-yl)guanidino)-N-(cyclohexyloxy)heptanamide 
• 1170235-17-2 N-benzyl-7-(2-cyano-1-(pyridin-4-yl)guanidino)-N-(cyclohexyloxy)heptanamide 
• 1170235-59-2 (S)-7-(2-cyano-1-(pyridin-4-yl)guanidino)-N-(cyclohexyloxy)-2-methylheptanamide 
• 1170235-48-9 (R)-7-(2-cyano-1-(pyridin-4-yl)guanidino)-N-(cyclohexyloxy)-2-methylheptanamide 
• 1170235-52-5 (S)-2-benzyl-7-(2-cyano-1-(pyridin-4-yl)guanidino)-N-(cyclohexyloxy)heptanamide 
• 1170235-60-5 (R)-2-benzyl-7-(2-cyano-1-(pyridin-4-yl)guanidino)-N-(cyclohexyloxy)heptanamide 
• 1170231-07-8 N-benzyl-O-cyclohexylhydroxylamine 
• 1033779-97-3 (E)-2-[2-(3-chloro-4-methanesulfonyl-phenyl)-2-cyclohexyloxyimino-acetylamino]-thiazole-5-carboxylic acid amide 
• 1033779-96-2 (E)-N-benzothiazol-2-yl-2-(3-chloro-4-methanesulfonyl-phenyl)-2-cyclohexyloxyimino-acetamide 
• 1033779-95-1 (E)-2-(3-chloro-4-methanesulfonyl-phenyl)-2-cyclohexyloxyimino-N-(3-methyl-[1,2,4]thiadiazol-5-yl)-acetamide 
• 1033779-94-0 (E)-2-(3-chloro-4-methanesulfonyl-phenyl)-2-cyclohexyloxyimino-N-(1-methyl-1H-pyrazol-3-yl)-acetamide 
• 1033780-23-2 (E)-(3-chloro-4-methanesulfonyl-phenyl)-cyclohexyloxyimino-acetic acid 

Relevant articles and documents

Copper-Catalyzed Domino Reactions for the Synthesis of Phenothiazines

A method for the one-pot synthesis of phenothiazines from benzothiazoles and aryl ortho-dihalides was explored. Preliminary work on the mechanism of the reaction suggested that it follows a domino process, including the hydrolysis of benzothiazoles followed by C-S coupling and C-N coupling. The low loading of the catalyst system (5 mol-% for both copper and ligand), the mild experimental conditions (90 °C, 12 h), and the use of a green reaction medium make this synthesis very attractive to academia and industry. A copper-catalyzed domino reaction consisting of the hydrolysis of benzothiazoles followed by C-S and C-N couplings for the synthesis of phenothiazines from benzothiazoles and aryl ortho-dihalides is described. The low loading of the catalyst system, mild experimental conditions, and the use of polyethylene glycol as the solvent make this synthetic approach very attractive to academia and industry.

Copper(II)-catalyzed cross dehydrogenative coupling reaction of N-hydroxyphthalimide with alkanes and ethers via unactivated C(sp3)-H activation at room temperature

A copper(ii)-catalyzed cross dehydrogenative coupling reaction between N-hydroxyphthalimide and unactivated C(sp3)-H bonds of alkanes and ethers using Selectfluor as an oxidant is described. This efficient reaction system shows mild conditions and a broad substrate scope for the generation of O-substituted N-hydroxyphthalimide derivatives.

Carbon-hydrogen bond activation method for non-metal participated inert alkane

The invention discloses an activation method of a non-metal catalyzed inert alkane carbon-hydrogen bond. The activation method comprises the following steps: S1, dissolving a compound inert alkane andN-hydroxyphthalimide into dichloromethane; S2, adding iodobenzene acetate into the system; S3, after N-hydroxyphthalimide disappears, carrying out reduced pressure distillation on the reaction systemto remove the low-boiling-point organic solvent; and S4, carrying out silica gel column chromatography separation to obtain the compound I. The method disclosed by the invention comprises the step ofadding the inert alkane compound into a solvent system of iodobenzene acetate and Nhydroxyphthalimide, so that the reaction condition is mild, heating is not needed, no metal participates, the methodis simple and efficient, the post-treatment is simple, inert gas or oxygen conditions are not needed, and the development concept of green chemistry is met.

Selective C(sp3)?H and C(sp2)?H Fluorination of Alcohols Using Practical Auxiliaries

Selective introduction of fluorine into molecules by the cleavage of inert C?H bonds is of central academic and synthetic interest, yet remains challenging. Given the central role of alcohols in organic chemistry as the most ubiquitous building blocks, a