170642-21-4

Basic information

• Product Name: Butanamide, 2-amino-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-, (2R)-
• CAS NO: 170642-21-4
• Molecular Formula: C14H22N2O2
• Molecular Weight: 250.341
• Mol File: 170642-21-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Butanamide, 2-amino-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanamide, 2-amino-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-, (2R)-(170642-21-4)
• EPA Substance Registry System: Butanamide, 2-amino-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-, (2R)-(170642-21-4)

Safety Data

• Hazardous Substances Data: 170642-21-4(Hazardous Substances Data)

Upstream product

• 170899-07-7 (S,S)-pseudoephedrine D-phenylalaninamide 
• 170642-22-5 (R)-2-Amino-3-cyclopropyl-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-propionamide 
• 52289-93-7 o-Methoxybenzyl bromide 
• 185508-77-4 {[((1S,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 75-03-6 ethyl iodide 
• 340039-87-4 C₁₅H₂₂N₂O₂S₂ 
• 170115-96-5 2-amino-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylacetamide 
• 74-96-4 ethyl bromide 
• 170642-33-8 (S,S)-pseudoephedrine N-methyl-D-phenylalaninamide 
• 185508-75-2 (S,S)-pseudoephedrine N-methylglycinamide 
• 170642-24-7 (R)-2-Amino-4-methyl-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide 
• 90-82-4 pseudoephedrine 

Downstream Products

• 90-82-4 pseudoephedrine 
• 45121-22-0 Boc-D-Abu 
• 185509-01-7 (S,S)-pseudoephedrine N-Boc-2-D-aminobutyramide 
• 170642-27-0 (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acid 
• 2623-91-8 (R)-2-aminobutyric acid 
• 170115-96-5 2-amino-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylacetamide 
• 185508-75-2 (S,S)-pseudoephedrine N-methylglycinamide 
• 170642-24-7 (R)-2-Amino-4-methyl-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide 
• 170642-32-7 (S,S)-pseudoephedrine D-pipecolinamide 
• 170642-33-8 (S,S)-pseudoephedrine N-methyl-D-phenylalaninamide 
• 170642-23-6 (S,S)-pseudoephedrine D-allylglycinamide 
• 170642-22-5 (R)-2-Amino-3-cyclopropyl-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-propionamide 
• 170899-07-7 (S,S)-pseudoephedrine D-phenylalaninamide 
• 170642-25-8 (R)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-3-(2-methoxy-phenyl)-N-methyl-propionamide 

Relevant articles and documents

The imine (+)-pseudoephedrine glycinamide: A useful reagent for the asymmetric synthesis of (R)-α-amino acids

The new imine derived from Myers (+)-pseudoephedrine glycinamide can be diastereoselectively alkylated with alkyl halides at room temperature using NaOEt or LiO-tert-Bu as bases under phase transfer conditions. Hydrolysis to the corresponding alkylated products was easily achieved under mild conditions to afford (R)-α-amino acids.

A practical method for the synthesis of D- or L-α-amino acids by the alkylation of (+)- or (-)-pseudoephedrine glycinamide

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