170935-34-9Relevant articles and documents
Incorporation Of 6-Thioguanosine Into Oligoribonucleotides
Adams, Chris J.,Murray, James B.,Farrow, Mark A.,Arnold, John R. P.,Stockley, Peter G.
, p. 5421 - 5424 (1995)
The preparation of N2-benzoyl-S6-cyanoethyl-6-thioguanosine and its incorporation into oligoribonucleotides, using standard phosphoramidite methods, is described. 6-Thioguanosine has been incorporated into the three guanosine sites of the central core of the hammerhead ribozyme resulting in 2- to 9-fold reductions in catalytic activity.