171774-27-9

Basic information

• Product Name: 6-methoxy-4-methyl-2-phenylquinoline
• Synonyms: 6-methoxy-4-methyl-2-phenylquinoline
• CAS NO: 171774-27-9
• Molecular Weight: 249.312
• Mol File: 171774-27-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 6-methoxy-4-methyl-2-phenylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methoxy-4-methyl-2-phenylquinoline(171774-27-9)
• EPA Substance Registry System: 6-methoxy-4-methyl-2-phenylquinoline(171774-27-9)

Safety Data

• Hazardous Substances Data: 171774-27-9(Hazardous Substances Data)

Upstream product

• 116-11-0 2-Methoxypropene 
• 783-08-4 [4-(benzylideneamino)phenyl]methanol 
• 20265-97-8 p-anisidine hydrochloride 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 100-52-7 benzaldehyde 
• 104-94-9 4-methoxy-aniline 
• 67-64-1 acetone 
• 41037-26-7 6-methoxy-4-methylquinoline 
• 591-51-5 phenyllithium 

Downstream Products

• 199168-75-7 6-methoxy-2-phenyl-quinoline-4-carbaldehyde 

Relevant articles and documents

Method for preparing 2-aryl-4-methyl quinoline compound

The invention discloses a method for preparing a 2-aryl-4-methyl quinoline compound. The method comprises the following steps of: adding fluoride and an alkynyl imine compound into an organic solvent, and heating to react completely, wherein the structural formula of the alkynyl imine compound is as shown in the specification, and the structural formula of the 2-aryl-4-methyl quinoline compound is a shown in the specification, in the formulas, R1 is hydrogen, halogen, methyl, methoxyl, thiophene or cyanogen radical; R2 is hydrogen, methyl or methoxyl. Compared with the prior art, the 2-aryl-4-methyl quinoline compound can be prepared from one organism of the alkynyl imine compound under the action of the fluoride at one stime. The method disclosed by the invention is easy to operate and simple and convenient in aftertreatmnet, and the designability of substrates is good.

Lanthanide triflate catalyzed imino Diels-Alder reactions; convenient syntheses of pyridine and quinoline derivatives

Lanthanide triflate catalyzed imino Diels-Alder reactions of imines with dienes or alkenes have been developed. A new group of Lewis acids, lanthanide triflates, are quite effective for the catalytic activation of imines. Unique reactivities of imines which work as both dienophiles and azadienes under certain conditions have been revealed. Three-component coupling reactions between aldehydes, amines, and dienes or alkenes were successfully carried out by using lanthanide triflate as a catalyst to afford pyridine and quinoline derivatives in high yields. The Lewis acid catalysts were stable and kept their activity even in the presence of water and amines. A stepwise reaction mechanism for these reactions is suggested from the experimental results.

Ytterbium(III) triflate catalyzed synthesis of quinoline derivatives from N-arylaldimines and vinyl ethers

[4 + 2] Cycloaddition reaction of N-arylaldimines with vinyl ethers is effectively catalyzed by ytterbium(III) triflate to give quinoline derivatives in good yields. Furthermore, the reaction with silyl enol ethers affords 4-siloxytetrahydroquinolines, whereas an imino aldol reaction takes place in the reaction with ketene silyl acetals.