17193-41-8

Basic information

• Product Name: (2RS,3RS)-2-amino-3-hydroxy-3-phenyl-propionic acid methyl ester; hydrochloride
• CAS NO: 17193-41-8
• Molecular Weight: 231.679
• Mol File: 17193-41-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2RS,3RS)-2-amino-3-hydroxy-3-phenyl-propionic acid methyl ester; hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2RS,3RS)-2-amino-3-hydroxy-3-phenyl-propionic acid methyl ester; hydrochloride(17193-41-8)
• EPA Substance Registry System: (2RS,3RS)-2-amino-3-hydroxy-3-phenyl-propionic acid methyl ester; hydrochloride(17193-41-8)

Safety Data

• Hazardous Substances Data: 17193-41-8(Hazardous Substances Data)

Upstream product

• 38061-23-3 α-Phenylacyl amino acid methyl ester hydrochloride 
• 67-56-1 methanol 
• 69-96-5 (2RS,3RS)-2-amino-3-hydroxy-3-phenyl-propionic acid 

Downstream Products

• 69-96-5 (2RS,3RS)-2-amino-3-hydroxy-3-phenyl-propionic acid 
• 17193-36-1 (±)-(2R,3R)-2-tert-butoxycarbonylamino-3-hydroxy-3-phenylpropionic acid methyl ester 
• 17193-36-1 (2S*,3R*)-2-tert-butoxycarbonylamino-3-hydroxy-3-phenyl-propionic acid methyl ester 
• 19185-84-3 (2SR,3SR)-N-benzoyl-β-phenylserine methyl ester 
• 255896-85-6 methyl (2R,3S)-threo-N-acetyl-β-phenylserinate 
• 101469-17-4 (2S,3R)-threo-N-acetyl-β-phenylserine 
• 17193-35-0 (2RS,3RS)-2-amino-3-hydroxy-3-phenyl-propionic acid amide 
• 17193-37-2 N-t-Butoxycarbonyl-threo-DL-β-phenyl-Ser-amid 
• 17193-35-0 (2RS,3SR)-2-amino-3-hydroxy-3-phenyl-propionic acid amide 

Relevant articles and documents

Asymmetric transfer hydrogenation of α-amino β-keto ester hydrochlorides through dynamic kinetic resolution

The development of Ru-catalyzed asymmetric transfer hydrogenation of α-amino β-keto ester hydrochlorides is described. The reaction proceeds through dynamic kinetic resolution to afford anti β-hydroxy α-amino esters with good diastereomeric ratios and high enantioselectivities.

Nitrate esters in the generation of amino acid radicals

Nitrate esters, prepared by treatment of β-hydroxy-α-amino acid derivatives with nitric acid, react with tributyltin hydride to give the corresponding alkoxyl radicals. These radicals readily undergo β-scission, providing a convenient route for the regiocontrolled production of α-carbon-centred amino acid radicals. By examining the partitioning of the alkoxyl radicals between the β-scission process and the competing hydrogen transfer reaction, it has been possible to evaluate the influence of electronic and steric effects on the β-scission reaction and the formation of the carbon-centred radicals.