172268-44-9

Basic information

• Product Name: 1-((R)-1-But-2-ynyl-hexyloxymethyl)-4-methoxy-benzene
• Synonyms: 1-((R)-1-But-2-ynyl-hexyloxymethyl)-4-methoxy-benzene
• CAS NO: 172268-44-9
• Molecular Weight: 274.403
• Mol File: 172268-44-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-((R)-1-But-2-ynyl-hexyloxymethyl)-4-methoxy-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((R)-1-But-2-ynyl-hexyloxymethyl)-4-methoxy-benzene(172268-44-9)
• EPA Substance Registry System: 1-((R)-1-But-2-ynyl-hexyloxymethyl)-4-methoxy-benzene(172268-44-9)

Safety Data

• Hazardous Substances Data: 172268-44-9(Hazardous Substances Data)

Upstream product

• 172268-43-8 (R)-2-(4-Methoxy-benzyloxy)-heptan-1-ol 
• 78843-64-8 (2R)-heptane-1,2-diol 
• 592-76-7 1-Heptene 
• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 4529-04-8 1-propynyl lithium 
• 172268-66-5 1-((R)-1-Bromomethyl-hexyloxymethyl)-4-methoxy-benzene 

Downstream Products

• 198192-89-1 (1Z,7E,13E)-(5R,9R,11R,12S,15S,17S)-17-(tert-Butyl-diphenyl-silanyloxy)-9,11-dihydroxy-8,10,10,12,14-pentamethyl-5-pentyl-4,19-dioxa-bicyclo[13.3.1]nonadeca-1,7,13-trien-3-one 
• 172268-48-3 [(2R,4S,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-methoxy-6-((1E,7E)-(3S,4R,6R,10R)-4,6,10-trihydroxy-1,3,5,5,7-pentamethyl-pentadeca-1,7-dienyl)-tetrahydro-pyran-2-yl]-acetic acid 
• 172268-71-2 [(2R,4S,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-((1E,7E)-(3S,4R,10R)-4,10-dihydroxy-1,3,5,5,7-pentamethyl-6-oxo-pentadeca-1,7-dienyl)-2-methoxy-tetrahydro-pyran-2-yl]-acetic acid ethyl ester 
• 172268-73-4 [(2R,4S,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-methoxy-6-((1E,7E)-(3S,4R,6R,10R)-4,6,10-trihydroxy-1,3,5,5,7-pentamethyl-pentadeca-1,7-dienyl)-tetrahydro-pyran-2-yl]-acetic acid ethyl ester 
• 198193-30-5 [(2R,4S,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-((1E,7E)-(3S,4R,10R)-6-hydroxy-1,3,5,5,7-pentamethyl-4,10-bis-triethylsilanyloxy-pentadeca-1,7-dienyl)-2-methoxy-tetrahydro-pyran-2-yl]-acetic acid ethyl ester 
• 172268-47-2 [(2R,4S,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-methoxy-6-((1E,7E)-(3S,4R,10R)-1,3,5,5,7-pentamethyl-6-oxo-4,10-bis-triethylsilanyloxy-pentadeca-1,7-dienyl)-tetrahydro-pyran-2-yl]-acetic acid ethyl ester 

Relevant articles and documents

Total syntheses of (+)-acutiphycin and (+)-trans-20,21-didehydroacutiphycin

The first total syntheses of the cytotoxic macrolides (+)-acutiphycin (1) and (+)-trans-20,21-didehydroacutiphycin (2) have been achieved. An acyclic stereocontrol strategy was employed to establish the configurations at C(5), C(10), and C(13) as well as the E geometry of the C(8,9)-trisubstituted olefin. Importantly, the natural source of 1 and 2, the blue-green alga Osillatoria acutissima, no longer produces these metabolites.