172268-48-3Relevant articles and documents
Total syntheses of (+)-acutiphycin and (+)-trans-20,21-didehydroacutiphycin
Smith III, Amos B.,Chen, Sean S.-Y.,Nelson, Frances C.,Reichert, Janice M.,Salvatore, Brian A.
, p. 10935 - 10946 (2007/10/03)
The first total syntheses of the cytotoxic macrolides (+)-acutiphycin (1) and (+)-trans-20,21-didehydroacutiphycin (2) have been achieved. An acyclic stereocontrol strategy was employed to establish the configurations at C(5), C(10), and C(13) as well as the E geometry of the C(8,9)-trisubstituted olefin. Importantly, the natural source of 1 and 2, the blue-green alga Osillatoria acutissima, no longer produces these metabolites.