172270-85-8

Basic information

• Product Name: Methyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate
• Synonyms: Methyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate
• CAS NO: 172270-85-8
• Molecular Formula: C₁₁H₁₆O₄
• Molecular Weight: 212.24234
• Mol File: 172270-85-8.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 312.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.16±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Methyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate(172270-85-8)
• EPA Substance Registry System: Methyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate(172270-85-8)

Safety Data

• Hazardous Substances Data: 172270-85-8(Hazardous Substances Data)

Upstream product

• 4746-97-8 cyclohexanedione monoethylene ketal 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 5927-18-4 trimethyl phosphonoacetate 
• 1067-74-9 Methyl diethylphosphonoacetate 

Downstream Products

• 202390-90-7 2-(1,4-Dioxa-spiro[4.5]dec-7-en-8-yl)-4-(2-iodo-5-methoxy-phenyl)-butyric acid methyl ester 
• 317338-46-8 methyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)acetate 
• 66405-41-2 (4-oxo-cyclohexyl)-acetic acid methyl ester 
• 1124174-16-8 methyl 2-((1r,4r)-4-hydroxycyclohexyl)acetate 
• 1268239-62-8 C₂₆H₂₉F₂N₃O₅ 
• 1268239-16-2 trans-6-[3-(2,3-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester 
• 1268239-40-2 trans-6-[3-(2-chloro-3-methyl-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester 
• 1268239-60-6 6-nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-methoxycarbonylmethyl-cyclohexyl ester 
• 1268239-61-7 6-amino-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-methoxycarbonylmethyl-cyclohexyl ester 
• 1268239-14-0 trans-6-[3-(2,4-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester 
• 1268239-64-0 C₂₆H₂₉F₂N₃O₅ 
• 1268239-88-8 C₂₇H₃₂ClN₃O₅ 
• 914780-95-3 1,4-dioxa-10-azadispiro[4.2.4⁸.2⁵]tetradecan-11-one 
• 914780-96-4 2-azaspiro[4.5]decane-3,8-dione 

Relevant articles and documents

CYCLOALKYLIDENE CARBOXYLIC ACIDS AND DERIVATIVES AS BTK INHIBITORS

The present invention relates to novel cycloalkylidene carboxylic acids and derivatives thereof useful as Bruton tyrosine kinase (BTK) inhibitors. The present disclosure also relates to processes for their preparation, pharmaceutical compositions containing one or more such compounds, and to the use of such compounds and pharmaceutical compositions for the treatment of disorders involving mediation of BTK in humans (Formula I).

PYRIMIDINE PYRAZOLYL DERIVATIVES

The present invention provides compounds of Formula (I) for the treatment of cancer, rheumatoid arthritis and other diseases (I).

NOVEL TETRAHYDROISOQUINOLINE DERIVATIVE

The present invention relates to a compound or a pharmacologically acceptable salt thereof having an excellent DGAT inhibitory effect and feeding suppressant effect. The present invention provides a compound represented by the general formula (I), or pharmacologically acceptable salt thereof: [wherein, R1 represents a phenylaminocarbonyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group A, a benzoxazol-2-yl group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group A, or the like; R2 independently represents a C1-C6 alkyl group; R3 represents a group represented by the formula -C(=O)-O-R4 or the like; R4 represents a hydrogen atom, a C1-C6 alkyl group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group B, or the like; X represents an oxygen atom, a methylene group, or a group represented by the formula -NH-, or the like; L represents a single bond, a methylene group, or the like;...... represents a single bond or a double bond; m represents 1 or 2; n represents an integer of 0 to 5; Substituent Group A represents a halogen atom, a C1-C6 alkyl group, a C1-C6 halogenated alkyl group, a C1-C6 alkoxy group, or the like; and Substituent Group B represents a C3-C6 cycloalkyl group, a phenyl group, a carboxyl group, or the like].