914780-95-3

Basic information

• Product Name: 1,4-dioxa-10-azadispiro[4.2.4⁸.2⁵]tetradecan-11-one
• Synonyms: 1,4-dioxa-10-azadispiro[4.2.4⁸.2⁵]tetradecan-11-one
• CAS NO: 914780-95-3
• Molecular Weight: 211.261
• Mol File: 914780-95-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1,4-dioxa-10-azadispiro[4.2.4⁸.2⁵]tetradecan-11-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-dioxa-10-azadispiro[4.2.4⁸.2⁵]tetradecan-11-one(914780-95-3)
• EPA Substance Registry System: 1,4-dioxa-10-azadispiro[4.2.4⁸.2⁵]tetradecan-11-one(914780-95-3)

Safety Data

• Hazardous Substances Data: 914780-95-3(Hazardous Substances Data)

Usage

Chemical structure

A complex organic compound with a unique structure, consisting of a spiro-linked system of two rings (one containing oxygen atoms and the other containing nitrogen atoms).

Synthesis

Synthesized through a combination of various chemical reactions and processes.

Natural occurrence

Not commonly found in nature.

Applications

Primarily used for research and experimental purposes in the field of organic chemistry.

Reactivity

Known for its high reactivity.

Potential uses

Has potential applications in the medicinal and pharmaceutical industries.

Ongoing research

Its precise uses and properties are still being explored by scientists and researchers.

Upstream product

• 4746-97-8 cyclohexanedione monoethylene ketal 
• 172270-85-8 8-(methoxyformylmethylene)-1,4-dioxaspiro[4.5]decane 
• 914780-94-2 methyl [8-(nitromethyl)-1,4-dioxaspiro[4.5]dec-8-yl]acetate 
• 51656-91-8 ethyl 1,4-dioxaspiro[4,5]dec-8-ylideneacetate 
• 1246508-12-2 ethyl 2-(8-(nitromethyl)-1,4-dioxaspiro-[4,5]-decan-8-yl-acetate) 

Downstream Products

• 914780-96-4 2-azaspiro[4.5]decane-3,8-dione 
• 1246508-13-3 10-benzyl-1,4-dioxa-10-azadispiro[4.2.4⁸.2⁵]tetradecan-11-one 
• 1272758-17-4 tert-butyl 8-oxo-2-azaspiro[4.5]decane-2-carboxylate 
• 1246508-14-4 10-benzyl-1,4-dioxa-10-azadispiro[4.2.4⁸.2⁵]tetradecane 

Relevant articles and documents

FACTOR XIIa INHIBITORS

The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIIa inhibitors.

Substituted heteroaryl compounds and compositions and uses thereof

The invention provides a substituted ceteroary compound as well as a composition and a purpose thereof. The substituted ceteroary compound is a compound shown as a formula (I) or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug of the pharmaceutically acceptable salt of the compound shown as the formula (I) and is used for regulating diseases or disorders mediated by one kind or various kinds of Janus kinase activities. The invention also provides a medicine composition containing the compound and a method of treating or alleviating the disease or disorder degree of a patient by inhibiting the Janus kinase activity.

SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE

The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, treating or lessening the severity of a JAK-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of JAK-mediated disease.