172613-65-9

Basic information

• Product Name: N-(2-oxo-1-phenyl-1-propyl)-carbamic acid tert-butyl ester
• Synonyms: N-(2-oxo-1-phenyl-1-propyl)-carbamic acid tert-butyl ester
• CAS NO: 172613-65-9
• Molecular Weight: 249.31
• Mol File: 172613-65-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 82-83 °C
• Boiling Point: 368.0±35.0 °C(Predicted)
• Density: 1.076±0.06 g/cm3(Predicted)
• CAS DataBase Reference: N-(2-oxo-1-phenyl-1-propyl)-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-oxo-1-phenyl-1-propyl)-carbamic acid tert-butyl ester(172613-65-9)
• EPA Substance Registry System: N-(2-oxo-1-phenyl-1-propyl)-carbamic acid tert-butyl ester(172613-65-9)

Safety Data

• Hazardous Substances Data: 172613-65-9(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 4248-19-5 tert-butyl carbazate 
• 3893-35-4 1-diazo-1-phenyl-2-propanone 
• 103-79-7 1-phenyl-acetone 
• 75-07-0 acetaldehyde 
• 155396-71-7 tert-butyl N-(phenyl(phenylsulfonyl)methyl)carbamate 
• 150884-50-7 benzaldehyde N-boc imine 
• 91230-12-5 (1-phenyl-allyl)-carbamic acid tert-butyl ester 
• 271600-36-3 N-[phenyl(toluene-4-sulfonyl)methyl]tert-butoxycarboxyamide 
• 75-16-1 methylmagnesium bromide 
• 143978-88-5 N-tert-butoxycarbonyl-L-phenylglycine methyl ester 

Downstream Products

• 526217-24-3 tert-butyl (1S,2R)-2-hydroxy-1-phenylpropylcarbamate 
• 52500-61-5 2-hydroxy-1-phenylpropylamine 
• 847150-25-8 tert-butyl 2-(2-methoxyphenylamino)-1-phenylethylcarbamate 

Relevant articles and documents

Asymmetric Transfer Hydrogenation: Dynamic Kinetic Resolution of α-Amino Ketones

A series of α-amino ketones were reduced using asymmetric transfer hydrogenation (ATH) through a dynamic kinetic resolution (DKR). The protecting group was matched to the reducing agent, and following optimization, a series of substrates were investigated, giving products in high diastereoselectivity, over 99% ee in several cases and full conversion. The methodology was applied to the enantioselective synthesis of an MDM2-p53 inhibitor precursor.

Enantioselective N-H insertion reaction of α-aryl α-diazoketones: An efficient route to chiral α-aminoketones

A highly enantioselective N-H insertion reaction of α-diazoketones was developed by using cooperative catalysis by dirhodium(II) carboxylates and chiral spiro phosphoric acids. The insertion reaction provides a new access route to diverse chiral α-aminoketones, which are versatile building blocks in organic synthesis, with fast reaction rates, good yields and high enantioselectivity under mild and neutral conditions. Spiro inspiration: A highly enantioselective N-H insertion reaction of α-diazoketones was developed by using cooperative catalysis by dirhodium(II) carboxylates and chiral spiro phosphoric acids. The insertion reaction provides a new access route to diverse chiral α-aminoketones, which are versatile building blocks in the organic synthesis, with fast reaction rates, good yields and high enantioselectivity under mild and neutral conditions.

Synthesis of acylated keto amides from sulfonyl amides

Acylated ketoamides are prepared from sulfonyl amides and aldehydes or their related derivatives by a step of