52500-61-5

Basic information

• Product Name: Beta-Amino-Alpha-methyl-benzeneethanol
• Synonyms: Beta-Amino-Alpha-methyl-benzeneethanol;b-Amino-a-methylphenethyl Alcohol;1-Amino-1-phenyl-2-propanol;1-Phenyl-2-hydroxypropylamine;Benzeneethanol, b-aMino-a-Methyl-
• CAS NO: 52500-61-5
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.20562
• Mol File: 52500-61-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 76-80℃
• Boiling Point: 288℃
• Flash Point: 128℃
• Appearance: /
• Density: 1.071
• Vapor Pressure: 0.0011mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: Beta-Amino-Alpha-methyl-benzeneethanol(CAS DataBase Reference)
• NIST Chemistry Reference: Beta-Amino-Alpha-methyl-benzeneethanol(52500-61-5)
• EPA Substance Registry System: Beta-Amino-Alpha-methyl-benzeneethanol(52500-61-5)

Safety Data

• Hazardous Substances Data: 52500-61-5(Hazardous Substances Data)

Usage

General Description

Beta-Amino-Alpha-methyl-benzeneethanol is a chemical compound that belongs to the class of aromatic alcohols. It is also known as Phendimetrazine, which functions as a stimulant and appetite suppressant, making it useful in the treatment of obesity. The chemical structure of Beta-Amino-Alpha-methyl-benzeneethanol includes a beta-amino group, an alpha-methyl group, and a benzene ring, giving it its pharmacological properties. It is commonly used in weight loss medications and has a potential for abuse and dependence due to its stimulating effects on the central nervous system. It is important to use this chemical under proper medical guidance and supervision to avoid potential side effects and health risks.

InChI:InChI=1/C9H13NO/c1-7(11)9(10)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3

Upstream product

• 25355-34-4 1-phenyl-propane-1,2-dione 1-oxime 
• 491-82-7 isoephedrine 
• 5300-22-1 (R/S)-2-(ethylamino)-1-phenylethanol 
• 160745-23-3 N-methylisoephedrine 
• 107002-91-5 1-Benzyloxyamino-1-phenyl-propan-2-ol 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 103-79-7 1-phenyl-acetone 
• 172613-65-9 N-(2-oxo-1-phenyl-1-propyl)-carbamic acid tert-butyl ester 
• 3904-16-3 1-amino-1-phenyl-propan-2-on hydrochloride 
• 88784-94-5 4-nitro-benzoic acid-((1RS,2RS)-2-hydroxy-1-phenyl-propylamide) 
• 127209-38-5 1-Dimethylsilanyl-2,2,3-trimethyl-4-phenyl-[1,2]azasiletidine 
• 122898-35-5 C₁₆H₁₇NO₃ 
• 90917-82-1 5-methyl-4-phenyl-4,5-dihydro-oxazol-2-ylamine 

Downstream Products

• 698-87-3 3-phenyl-2-propanol 
• 2165-67-5 (1RS,2SR)-1-amino-1-cyclohexyl-propan-2-ol 
• 88784-94-5 4-nitro-benzoic acid-((1RS,2SR)-2-hydroxy-1-phenyl-propylamide) 
• 88122-90-1 (+/-)-5c-methyl-2,4r-diphenyl-4,5-dihydro-oxazole 
• 160745-23-3 N-methylisoephedrine 
• 90917-82-1 5-methyl-4-phenyl-4,5-dihydro-oxazol-2-ylamine 
• 127744-61-0 (1S,2R)-1-Phenyl-2-{[1-thiophen-2-yl-meth-(E)-ylidene]-amino}-propan-1-ol 
• 174635-64-4 N-[α-(1-hydroxyethyl)benzyl]-2-phenylquinoline-4-carboxamide 
• 19901-87-2 (1R,2S/1R,2R)-1-amino-1-phenylpropan-2-ol 
• 88784-94-5 4-nitro-benzoic acid-((1RS,2RS)-2-hydroxy-1-phenyl-propylamide) 
• 174636-55-6 (R,S)-N-[α-(1-hydroxyethyl)benzyl]-3-methyl-2-phenylquinoline-4-carboxamide 

Relevant articles and documents

Regio- and stereoselective multi-enzymatic aminohydroxylation of β-methylstyrene using dioxygen, ammonia and formate

We report an enzymatic route for the formal regio- and stereoselective aminohydroxylation of β-methylstyrene that consumes only dioxygen, ammonia and formate; carbonate is the by-product. The biocascade entails highly selective epoxidation, hydrolysis and hydrogen-borrowing alcohol amination. Thus, β-methylstyrene was converted into 1R,2R and 1S,2R-phenylpropanolamine in 59-63% isolated yields, and up to >99.5 : 0.5 dr and er.

2-AMINOOXAZOLINES AS TAAR1 LIGANDS

The invention relates to compounds of formula (I) wherein R1 is halogen; R2 is lower alkyl or lower alkyl substituted by halogen; R2' is hydrogen, lower alkyl or lower alkyl substituted by halogen; X is a bond, -CH2-, -CH2CH2- or -CH2CH2CH2-; Y is phenyl or cyclohexyl; and n is 0, 1 or 2; or to a pharmaceutically suitable acid addition salt thereof. The compounds of formula I are active on the TAAR1 receptor and are therefore suitable for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson's disease, neurodegenerative disorders, Alzheimer's disease, epilepsy, migraine, substance abuse and metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.

PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSYNE KINASES

Compounds of formula (I): and their use in the inhibition of Trk activity are described.