172900-72-0

Basic information

• Product Name: (4R)-3-{(2R)-2-{[4-methoxy-3-(methoxypropoxy)phenyl]methyl-3-methyl}-1-oxobutyl}-4-(phenylmethyl)oxazolidin-2-one
• Synonyms: (4R)-3-{(2R)-2-{[4-methoxy-3-(methoxypropoxy)phenyl]methyl-3-methyl}-1-oxobutyl}-4-(phenylmethyl)oxazolidin-2-one
• CAS NO: 172900-72-0
• Molecular Weight: 469.578
• Mol File: 172900-72-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (4R)-3-{(2R)-2-{[4-methoxy-3-(methoxypropoxy)phenyl]methyl-3-methyl}-1-oxobutyl}-4-(phenylmethyl)oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R)-3-{(2R)-2-{[4-methoxy-3-(methoxypropoxy)phenyl]methyl-3-methyl}-1-oxobutyl}-4-(phenylmethyl)oxazolidin-2-one(172900-72-0)
• EPA Substance Registry System: (4R)-3-{(2R)-2-{[4-methoxy-3-(methoxypropoxy)phenyl]methyl-3-methyl}-1-oxobutyl}-4-(phenylmethyl)oxazolidin-2-one(172900-72-0)

Safety Data

• Hazardous Substances Data: 172900-72-0(Hazardous Substances Data)

Upstream product

• 40217-17-2 (R)-4-(phenylmethyl)-2-oxazolidinone 
• 145589-03-3 (R)-4-benzyl-3-(3-methylbutyryl)oxazolidin-2-one 
• 172900-75-3 4-methoxy-3-(3-methoxypropoxy)benzaldehyde 
• 1179062-77-1 4-chloromethyl-1-methoxy-2-(3-methoxypropoxy)-benzene 
• 1381757-32-9 C₁₂H₁₇IO₃ 
• 108-12-3 isopentanoyl chloride 
• 4039-32-1 lithium hexamethyldisilazane 
• 172900-73-1 4-(bromomethyl)-1-methoxy-2-(3-methoxypropoxy)-benzene 
• 148433-01-6 3-(3-bromopropoxy)-4-methoxybenzaldehyde 
• 172900-74-2 [4-methoxy-3-(3-methoxypropoxy)-phenyl]methanol 
• 621-59-0 isovanillin 

Downstream Products

• 324763-39-5 (R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane 
• 325154-26-5 (2S,7R,E)-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-N,N,8-trimethylnon-4-enamide 
• 955021-69-9 tert-butyl (2S,3S,5S)-5-(3-(3-methoxypropoxy)-4-methoxybenzyl)-1-(1,1-dioxo-4-(phenethylamino)-1,2,5-thiadiazol-3-ylamino)-2-hydroxy-6-methylheptan-3-ylcarbamate 
• 955021-57-5 3-((2S,3S,5S)-5-(3-(3-methoxypropoxy)-4-methoxybenzyl)-3-(tert-butoxycarbonylamino)-2-hydroxy-6-methylheptylamino)-4-(N-methyl-N-(2-methylpentan-2-yl)amino)cyclobut-3-ene-1,2-dione 
• 955020-83-4 3-((2S,3S,5S)-5-(3-(3-methoxypropoxy)-4-methoxybenzyl)-3-(tert-butoxycarbonylamino)-2-hydroxy-6-methylheptylamino)-4-(benzylamino)cyclobut-3-ene-1,2-dione 
• 955021-64-4 3-((2S,3S,5S)-5-(3-(3-methoxypropoxy)-4-methoxybenzyl)-3-(tert-butoxycarbonylamino)-2-hydroxy-6-methylheptylamino)-4-hexylcyclobut-3-ene-1,2-dione 
• 955020-76-5 (4S)-tert-butyl 4-(3-(3-methoxypropoxy)-4-methoxybenzyl)-2-(diphenylmethyleneamino)-5-methylhexanoate 
• 905830-90-2 tert-butyl (3S)-1-(tert-butoxycarbonyl)-3-(3-(3-methoxypropoxy)-4-ethylbenzyl)-4-methylpentyl-carbamate 
• 905830-91-3 tert-butyl (4S)-4-(3-(3-methoxypropoxy)-4-methoxybenzyl)-1-hydroxy-5-methylhexan-2-ylcarbamate 
• 905830-92-4 tert-butyl (3S)-3-(3-(3-methoxypropoxy)-4-methoxybenzyl)-1-formyl-4-methylpentylcarbamate 
• 861901-11-3 tert-butyl {1(S)-(2-amino-1(S)-hydroxyethyl)-3(S)-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl}carbamate 
• 656241-21-3 methyl (2S,4S)-2-{[(tert-butoxy)carbonyl]amino}-4-[4-methoxy-3-(3-methoxypropoxy)benzyl]-5-methylhexanoate 
• 656241-17-7 (2S,5R)-2,5-dihydro-3,6-dimethoxy-2-{(2S)-2-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-3-methylbutyl}-5-(1-methylethyl)pyrazine 
• 656241-37-1 (2R,4S)-2-Amino-4-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-5-methyl-hexanoic acid methyl ester 

Relevant articles and documents

Convergent Synthesis of the Renin Inhibitor Aliskiren Based on C5-C6 Disconnection and CO2H-NH2 Equivalence

A novel synthesis of the renin inhibitor aliskiren based on an unprecedented disconnection between C5 and C6 was developed, in which the C5 carbon acts as a nucleophile and the amino group is introduced by a Curtius rearrangement, which follows a simultaneous stereocontrolled generation of the C4 and C5 stereogenic centers by an asymmetric hydrogenation. Operational simplicity, step economy, and a good overall yield makes this synthesis amenable to manufacture on scale.

AN IMPROVED PROCESS FOR THE PREPARATION OF ALISKIREN

The present invention relates to an improved process for the preparation of renin inhibitor Aliskiren intermediates of Formula-II and further conversion into Aliskiren and its pharmaceutically acceptable salts.

1-HETEROCYCLYLAMINO-2-HYDROXY-3-AMINO-ω-ARYLALKANES

1-Heterocyclylamino-2-hydroxy-3-amino-?-arylalkanes of formula (I) and the salts thereof have renin-inhibiting properties and can be used as antihypertensive, medicinally active ingredients.