173101-56-9 Usage
Description
NITINE(BENZYL ANALOG OF TAXOL)(P) is a chemical compound that serves as a derivative of the well-known chemotherapeutic agent, Taxol. It is specifically a benzyl analog, which means it has a benzyl group attached to its structure. This modification is intended to enhance the compound's properties, such as solubility, stability, or bioavailability, and potentially improve its therapeutic effects.
Uses
Used in Anticancer Applications:
NITINE(BENZYL ANALOG OF TAXOL)(P) is used as an antineoplastic agent for the treatment of various types of cancer. It is particularly effective against solid malignancies such as lung, ovarian, breast, and head and neck cancers, as well as advanced forms of Kaposi's sarcoma. As a mitotic inhibitor, it plays a crucial role in cancer chemotherapy by disrupting the normal cell division process, thereby inhibiting tumor growth and progression.
Used in the Study of Microtubules:
NITINE(BENZYL ANALOG OF TAXOL)(P) is also utilized in the study of the structure and function of microtubules, which are essential components of the cytoskeleton in eukaryotic cells. By interacting with tubulin, a protein that forms the building blocks of microtubules, this compound can provide valuable insights into the mechanisms underlying microtubule dynamics and their role in cellular processes.
Used in Drug Development and Optimization:
As an analog of Taxol, NITINE(BENZYL ANALOG OF TAXOL)(P) is employed in the development and optimization of new chemotherapeutic drugs. Its unique structure allows researchers to explore the potential of modifying existing drugs to improve their efficacy, reduce side effects, and overcome drug resistance in cancer treatment.
Used in Drug Delivery Systems:
NITINE(BENZYL ANALOG OF TAXOL)(P) can be incorporated into drug delivery systems to enhance its therapeutic potential. By using various carriers, such as organic and metallic nanoparticles, the compound's delivery, bioavailability, and overall effectiveness against cancer cells can be significantly improved. This approach can also help to minimize potential side effects and increase the compound's selectivity for cancer cells, thus reducing damage to healthy tissues.
Check Digit Verification of cas no
The CAS Registry Mumber 173101-56-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,3,1,0 and 1 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 173101-56:
(8*1)+(7*7)+(6*3)+(5*1)+(4*0)+(3*1)+(2*5)+(1*6)=99
99 % 10 = 9
So 173101-56-9 is a valid CAS Registry Number.
173101-56-9Relevant articles and documents
Structure-activity relationship study of taxoids for their ability to activate murine macrophages as well as inhibit the growth of macrophage-like cells
Ojima, Iwao,Fumero-Oderda, Cecilia L.,Kuduk, Scott D.,Ma, Zhuping,Kirikae, Fumiko,Kirikae, Teruo
, p. 2867 - 2888 (2003)
A series of new taxoids modified at the C-3′, C-3′N, C-10, C-2 and C-7 positions has been designed, synthesized and evaluated for their potency to induce NO and TNF production by peritoneal murine macrophages (Mφ) from LPS-responsive C3H/HeN and LPS-hyporesponsive C3H/HeJ strains and human blood cells, and for their ability to inhibit the growth of Mφ-like cell lines J774.1 and J7.DEF3. The SAR-study has shown that the nature of the substituents at these positions have critical effect on the induction of TNF and NO production by Mφ. Positions C-3′ and C-10 are the most flexible and an intriguing effect of the length of the substituents at the C-10 position is observed for taxoids bearing a straight chain alkanoyl moiety. An aromatic group at the C-3′N and C-2 positions is required for the activity, while only hydroxyl or acetyl substituents seem to be tolerated at the C-7 position. The natural stereochemistry in the C-13 isoserine side chain of the taxoids is an absolute requirement for macrophage activation. It has also been clearly shown that there is no correlation between the ability of the taxoids to induce TNF/NO production in C3H/HeN Mφ and the cytotoxicity against Mφ-like cells.
