17336-08-2

Basic information

• Product Name: Benzoic acid, 2-(acetyloxy)-4-chloro-
• CAS NO: 17336-08-2
• Molecular Formula: C9H7ClO4
• Molecular Weight: 214.605
• Mol File: 17336-08-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-(acetyloxy)-4-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-(acetyloxy)-4-chloro-(17336-08-2)
• EPA Substance Registry System: Benzoic acid, 2-(acetyloxy)-4-chloro-(17336-08-2)

Safety Data

• Hazardous Substances Data: 17336-08-2(Hazardous Substances Data)

Upstream product

• 5106-98-9 4-chlorosalicylic acid 
• 75-36-5 acetyl chloride 
• 65-49-6 4-Aminosalicylic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 1237518-81-8 tert-butyl 2-(2-acetoxy-4-chlorobenzamido)-4-phenylbenzoate 
• 1415566-82-3 C₁₂H₈ClN₃O₅S 
• 1148-48-7 7-chloro-2-phenyl-4H-1-benzopyran-4-one 
• 1237514-37-2 2-(4-chloro-2-hydroxybenzamido)-4-phenylbenzoic acid 
• 1237518-82-9 tert-butyl 2-(4-chloro-2-hydroxybenzamido)-4-phenylbenzoate 
• 54551-50-7 2-acetoxy-4-chlorobenzoic acid chloride 
• 1706-82-7 3-chloro-2,4,6-trinitro-phenol 
• 45868-31-3 5-chlorosalicylate 

Relevant articles and documents

Synthesis and antioxidant activities of berberine 9-: O -benzoic acid derivatives

Although berberine (BBR) shows antioxidant activity, its activity is limited. We synthesized 9-O-benzoic acid berberine derivatives, and their antioxidant activities were screened via ABTS, DPPH, HOSC and FRAP assays. The para-position was modified with halogen elements on the benzoic acid ring, which led to an enhanced antioxidant activity and the substituent on the ortho-position was found to be better than the meta-position. Compounds 8p, 8c, 8d, 8i, 8j, 8l, and especially 8p showed significantly higher antioxidant activities, which could be attributed to the electronic donating groups. All the berberine derivatives possessed proper lipophilicities. In conclusion, compound 8p is a promising antioxidant candidate with remarkable elevated antioxidant activity and moderate lipophilicity.

Development of 5-nitrothiazole derivatives: Identification of leads against both replicative and latent Mycobacterium tuberculosis

Twenty eight 5-nitrothiazole derivatives were synthesized and evaluated for in vitro activities against Mycobacterium tuberculosis (MTB), cytotoxicity against HEK 293T. Among the compounds, 5-nitro-N-(5-nitrothiazol-2-yl)furan-2- carboxamide (20) was found to be the most active compound in vitro with MICs of 5.48 μM against log-phase culture of MTB and also non-toxic up to 100 μM.

4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

The structure-based design of potent and selective urokinase-type plasminogen activator (uPA) inhibitors with 4-aminoarylamidine or 4-aminoarylguanidine S1 binding groups, is described.