17356-28-4

Basic information

• Product Name: 2H-Azepin-2-one, hexahydro-1-(2-propenyl)-
• Synonyms: 2H-Azepin-2-one, hexahydro-1-(2-propenyl)-;1-Allylhexahydro-1H-azepine-2-one;Hexahydro-1-(2-propenyl)-2H-azepin-2-one
• CAS NO: 17356-28-4
• Molecular Formula: C₉H₁₅NO
• Molecular Weight: 153.22
• Mol File: 17356-28-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2H-Azepin-2-one, hexahydro-1-(2-propenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Azepin-2-one, hexahydro-1-(2-propenyl)-(17356-28-4)
• EPA Substance Registry System: 2H-Azepin-2-one, hexahydro-1-(2-propenyl)-(17356-28-4)

Safety Data

• Hazardous Substances Data: 17356-28-4(Hazardous Substances Data)

Usage

Use

Synthesis of pharmaceutical drugs and natural products

Structure

Cyclic amide with a six-membered ring containing nitrogen and oxygen

Physical Properties

Colorless to pale yellow liquid with a slightly sweet and nutty odor

Applications

Potential use in the pharmaceutical industry, of interest to researchers for its chemical and biological properties

Upstream product

• 105-60-2 caprolactam 
• 106-95-6 allyl bromide 
• 92954-34-2 O-allyl-N,N'-dicyclohexyl isourea 
• 1606141-48-3 6-(allyl(tert-butoxycarbonyl)amino)hexanoic acid 
• 1606141-51-8 2-(anthracen-9-yl)ethyl 6-(allyl(tert-butoxycarbonyl)amino)hexanoate 
• 1606141-55-2 2-(anthracen-9-yl)ethyl 6-(allylamino)hexanoate 

Downstream Products

• 105-60-2 caprolactam 
• 222048-38-6 2-[1-Allyl-azepan-(2E)-ylidene]-1-(4-chloro-phenyl)-ethanone 

Relevant articles and documents

SYNTHESIS AND BACTERICIDAL ACTIVITY OF N-ALLYLLACTAMS

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Hydrolytic deallylation of N-allyl amides catalyzed by PdII complexes

Hydrolytic deallylation of N-allyl amides to give amides and propanal can be achieved with PdII catalysts. The optimized catalyst consists of Pd(OCOCF3)2 and 1,3-bis(diphenylphosphanyl) propane (DPPP). Several kinds of open-chain N-allyl amides and N-allyl lactams undergo hydrolytic deallylation to give the corresponding amides and lactams in good to high yield. A mechanism which includes isomerization to enamides and subsequent hydrolysis is proposed. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

Direct N-Allylation of Amides with 2-Allylisourea Catalyzed by Palladium(0)

Direct N-allylation of amides catalyzed by palladium(0) complexes took place under neutral conditions by the use of 2-allylisourea as the allylating agent.