174072-89-0Relevant articles and documents
Preparation method of Rugolix key intermediate
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Paragraph 0058-0061, (2020/08/02)
The invention relates to a preparation method of a Rugolix key intermediate. 4-nitrophenyl acetic acid is used as a raw material, and a target product is obtained through four steps of reaction. The preparation method avoids the use of toxic reagents and has the advantages of mild reaction conditions, low cost, high yield and simple route and is suitable for industrial large-scale production.
Heterocyclyl-substituted thieno[2,3-d]pyrimidine-2,4-(1H,3H)-diketone compound and application thereof
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Paragraph 0141; 0147-0151, (2020/11/22)
The invention belongs to the technical field of medicines, and relates to heterocyclyl-substituted thieno[2,3-d]pyrimidine-2,4-(1H,3H)-diketone compounds and application thereof, and a pharmaceuticalcomposition containing the compounds; wherein the compounds and the pharmaceutical composition can be used as gonadotropin releasing hormone receptor antagonists. The invention also relates to a method for preparing the compound and the pharmaceutical composition, and application of the compounds and the pharmaceutical compositions in prevention or treatment of sex hormone dependent diseases, including but not limited to: prostate cancer, endometriosis, hysteromyoma, precocious puberty and the like.
Nitrogen-containing heterocyclic group substituted pyrimidinedione compound and application thereof
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Paragraph 0139; 0144; 0145; 0146; 0147, (2020/11/23)
The invention belongs to the technical field of medicines, and relates to a nitrogen-containing heterocyclic group substituted pyrimidinedione compound and application thereof, and a pharmaceutical composition containing the compound, which can be used as a gonadotropin releasing hormone receptor antagonist. The invention also relates to a method for preparing the compound and the pharmaceutical composition, and application of the compound and the pharmaceutical composition in prevention or treatment of sex hormone dependent diseases including but not limited to prostate cancer, endometriosis,hysteromyoma, precocious puberty and the like.