174264-46-1

Basic information

• Product Name: 4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene
• Synonyms: 4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene;[2-[4-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]phenyl]-6-hydroxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]Methanone;6-Hydroxy-4'-tert-butyldiMethylsylyl Raloxifene;4a€-tert-Butyldimethylsilyl-6-hydroxy Raloxifene
• CAS NO: 174264-46-1
• Molecular Formula: C₃₄H₄₁NO₄SSi
• Molecular Weight: 587.84414
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 174264-46-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 706.195°C at 760 mmHg
• Flash Point: 380.893°C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: Refrigerator
• Solubility: Acetone, Chloroform, Dichloromethane, Ethanol, Methanol
• CAS DataBase Reference: 4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene(CAS DataBase Reference)
• NIST Chemistry Reference: 4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene(174264-46-1)
• EPA Substance Registry System: 4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene(174264-46-1)

Safety Data

• Hazardous Substances Data: 174264-46-1(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

Protected Raloxifene

InChI:InChI=1/C34H41NO4SSi/c1-34(2,3)41(4,5)39-28-16-11-25(12-17-28)33-31(29-18-13-26(36)23-30(29)40-33)32(37)24-9-14-27(15-10-24)38-22-21-35-19-7-6-8-20-35/h9-18,23,36H,6-8,19-22H2,1-5H3

Upstream product

• 84449-90-1 Raloxifen 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 185416-86-8 2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-6-[[(trifluoromethyl)sulfonyl]oxy]benzo[b]thiophen-3-yl 4-[2-(1-piperidinyl)ethoxy]phenyl ketone 
• 174264-49-4 (2S,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-{2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-6-yloxy}-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 189940-52-1 2-(4-hydroxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]benzo[b]thiophene-6-carboxylic acid methyl ester 

Relevant articles and documents

Benzo?b!thiophene compounds, intermediates, formulations, and methods

This invention relates to the field of pharmaceutical and organic chemistry and provides benzothiophene compounds, intermediates, formulations, and methods.

Benzo (b) thiophene compounds, intermediates, formulations, and methods

A class of 6-(dialkylphosphonyl)benzo[b]thiophene compounds are useful in the treatment of bone loss, hyperlipidemia, and estrogen-dependent cancer.

Synthesis and estrogen receptor binding affinities of the major human metabolites of raloxifene (LY139481)

Glucuronide conjugates 1 and 2, the major metabolites of raloxifene, have been prepared and their molecular interactions with the estrogen receptor determined.