174264-49-4 Usage
Description
Methyl-1-(4’-tert-butyldimethylsylyl-6-hydroxyraloxifene)-2,3,4-tri-O-acetyl--D-glycopyranuronate is a complex organic compound that serves as an intermediate in the synthesis of the metabolite of Raloxifene. Raloxifene is a nonsteroidal estrogen receptor mixed agonist/antagonist, which means it can both activate and inhibit the effects of estrogen in the body. Methyl-1-(4’-tert-butyldimethylsylyl-6-hydroxyraloxifene)-2,3,4-tri-O-acetyl--D-glycopyranuronate is characterized by its unique chemical structure, which includes a methyl group, a tert-butyldimethylsylyl group, and a hydroxyraloxifene moiety, among other functional groups.
Uses
Used in Pharmaceutical Industry:
Methyl-1-(4’-tert-butyldimethylsylyl-6-hydroxyraloxifene)-2,3,4-tri-O-acetyl--D-glycopyranuronate is used as an intermediate in the synthesis of the metabolite of Raloxifene for the pharmaceutical industry. The application reason is that Raloxifene has been found to have potential therapeutic effects in treating osteoporosis, breast cancer, and other conditions related to estrogen receptor activity. By using this compound as an intermediate, researchers and pharmaceutical companies can develop more effective and targeted therapies for these conditions.
Used in Research and Development:
In addition to its use in the pharmaceutical industry, Methyl-1-(4’-tert-butyldimethylsylyl-6-hydroxyraloxifene)-2,3,4-tri-O-acetyl--D-glycopyranuronate can also be used in research and development for the study of estrogen receptor modulators and their potential applications in various medical fields. The compound's unique structure allows researchers to explore its interactions with estrogen receptors and investigate its potential as a therapeutic agent or as a tool for understanding the underlying mechanisms of estrogen-related diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 174264-49-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,4,2,6 and 4 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 174264-49:
(8*1)+(7*7)+(6*4)+(5*2)+(4*6)+(3*4)+(2*4)+(1*9)=144
144 % 10 = 4
So 174264-49-4 is a valid CAS Registry Number.
174264-49-4Relevant articles and documents
Synthesis and estrogen receptor binding affinities of the major human metabolites of raloxifene (LY139481)
Dodge, Jeffrey A.,Lugar, Charles W.,Cho, Stephen,Osborne, John J.,Phillips, David L.,Glasebrook, Andrew L.,Frolik, Charles A.
, p. 993 - 996 (1997)
Glucuronide conjugates 1 and 2, the major metabolites of raloxifene, have been prepared and their molecular interactions with the estrogen receptor determined.
