174264-48-3

Basic information

• Product Name: Methyl-1-(6-tert-butyldimethylsylyl-4’-hydroxyraloxifene)-2,3,4-tri-O-acetyl--D-glycopyranuronate
• Synonyms: Methyl-1-(6-tert-butyldimethylsylyl-4’-hydroxyraloxifene)-2,3,4-tri-O-acetyl--D-glycopyranuronate;4-[6-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]benzo[b]thien-2-yl]phenyl β-D-Glucopyranosiduronic Acid Methyl Ester 2,3,4-Triacetate;YPNOPKDREFSCOE-UHFFFAOYSA-N
• CAS NO: 174264-48-3
• Molecular Formula: C₄₇H₅₇NO₁₃SSi
• Molecular Weight: 904.10488
• Product Categories: Intermediates & Fine Chemicals;Metabolites;Pharmaceuticals
• Mol File: 174264-48-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Methyl-1-(6-tert-butyldimethylsylyl-4’-hydroxyraloxifene)-2,3,4-tri-O-acetyl--D-glycopyranuronate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl-1-(6-tert-butyldimethylsylyl-4’-hydroxyraloxifene)-2,3,4-tri-O-acetyl--D-glycopyranuronate(174264-48-3)
• EPA Substance Registry System: Methyl-1-(6-tert-butyldimethylsylyl-4’-hydroxyraloxifene)-2,3,4-tri-O-acetyl--D-glycopyranuronate(174264-48-3)

Safety Data

• Hazardous Substances Data: 174264-48-3(Hazardous Substances Data)

Usage

Description

Methyl-1-(6-tert-butyldimethylsylyl-4’-hydroxyraloxifene)-2,3,4-tri-O-acetyl--D-glycopyranuronate is a complex organic compound that serves as an intermediate in the synthesis of the metabolite of Raloxifene. Raloxifene is a nonsteroidal estrogen receptor mixed agonist/antagonist, which means it can both activate and inhibit the effects of estrogen in the body. Methyl-1-(6-tert-butyldimethylsylyl-4’-hydroxyraloxifene)-2,3,4-tri-O-acetyl--D-glycopyranuronate is characterized by its orange foam appearance and is used in the pharmaceutical industry for the development of drugs that target estrogen receptor-related conditions.

Uses

Used in Pharmaceutical Industry:
Methyl-1-(6-tert-butyldimethylsylyl-4’-hydroxyraloxifene)-2,3,4-tri-O-acetyl--D-glycopyranuronate is used as an intermediate in the synthesis of Raloxifene metabolites for the development of pharmaceutical drugs. The application reason is its role in creating a nonsteroidal estrogen receptor mixed agonist/antagonist, which can be used to treat conditions related to estrogen receptor activity, such as osteoporosis and certain types of cancer.
Used in Synthesis of Raloxifene Metabolites:
Methyl-1-(6-tert-butyldimethylsylyl-4’-hydroxyraloxifene)-2,3,4-tri-O-acetyl--D-glycopyranuronate is used as a key component in the synthesis process of Raloxifene metabolites. The application reason is its ability to facilitate the creation of a compound with mixed agonist/antagonist properties, which can be beneficial in the treatment of various medical conditions.
Chemical Properties:
The chemical properties of Methyl-1-(6-tert-butyldimethylsylyl-4’-hydroxyraloxifene)-2,3,4-tri-O-acetyl--D-glycopyranuronate include its orange foam appearance, which may be indicative of its unique structural and functional characteristics. This property could be relevant in the identification, handling, and further processing of the compound in the context of pharmaceutical research and development.

Upstream product

• 3082-96-0 methyl 1,2,3,4-tetra-O-acetyl-α,β-D-glucopyranosyluronate 
• 174264-47-2 (6-((tert-butyldimethylsilyl)oxy)-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone 
• 84449-90-1 Raloxifen 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 182507-22-8 Raloxifene-4'-beta-glucuronide 

Relevant articles and documents

Synthesis and estrogen receptor binding affinities of the major human metabolites of raloxifene (LY139481)

Glucuronide conjugates 1 and 2, the major metabolites of raloxifene, have been prepared and their molecular interactions with the estrogen receptor determined.