182507-22-8 Usage
Description
RALOXIFENE-4-GLUCURONIDE is a metabolite of Raloxifene, a nonsteroidal estrogen receptor mixed agonist/antagonist. It is a yellow solid that can be used as a labelled metabolite for various applications.
Uses
Used in Pharmaceutical Industry:
RALOXIFENE-4-GLUCURONIDE is used as a metabolite for Raloxifene, a nonsteroidal estrogen receptor mixed agonist/antagonist, for the development and study of drugs targeting estrogen receptors.
Used in Research and Development:
RALOXIFENE-4-GLUCURONIDE is used as a labelled metabolite for research and development purposes, allowing for the tracking and analysis of Raloxifene's metabolism and its effects on the body.
Used in Quantification and Analysis:
RALOXIFENE-4-GLUCURONIDE can be intended for use as an internal standard for the quantification of Raloxifene by GCor LC-mass spectrometry, ensuring accurate measurements and analysis in various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 182507-22-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,2,5,0 and 7 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 182507-22:
(8*1)+(7*8)+(6*2)+(5*5)+(4*0)+(3*7)+(2*2)+(1*2)=128
128 % 10 = 8
So 182507-22-8 is a valid CAS Registry Number.
InChI:InChI=1/C34H35NO10S/c36-21-8-13-24-25(18-21)46-32(20-6-11-23(12-7-20)44-34-30(40)28(38)29(39)31(45-34)33(41)42)26(24)27(37)19-4-9-22(10-5-19)43-17-16-35-14-2-1-3-15-35/h4-13,18,28-31,34,36,38-40H,1-3,14-17H2,(H,41,42)/t28-,29-,30-,31?,34+/m1/s1
182507-22-8Relevant articles and documents
Synthesis and estrogen receptor binding affinities of the major human metabolites of raloxifene (LY139481)
Dodge, Jeffrey A.,Lugar, Charles W.,Cho, Stephen,Osborne, John J.,Phillips, David L.,Glasebrook, Andrew L.,Frolik, Charles A.
, p. 993 - 996 (2007/10/03)
Glucuronide conjugates 1 and 2, the major metabolites of raloxifene, have been prepared and their molecular interactions with the estrogen receptor determined.
