174309-28-5Relevant articles and documents
SUBSTITUTED PHENYLOXAZOLIDINONES FOR ANTIMICROBIAL THERAPY
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, (2017/02/09)
The present invention relates to novel oxazolidinones (Formula I): or a pharmaceutically acceptable salt having ring A characterized by N-containing monocyclic, bicyclic or spirocyclic substituents, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.
Practical synthesis of 3-oxa-6-azabicyclo[31.1]heptane hydrotosylate; A novel morpholine-based building block
Walker, Daniel P.,Eklov, Brian M.,Bedore, Matthew W.
, p. 2859 - 2862 (2012/11/13)
Bridged bicyclic morpholines are important building blocks in medicinal chemistry research. The bicyclic morpholine 3-oxa-6-azabicylo[3.1.1]heptane (3a) is of particular interest as a morpholine isostere because it is achiral and shows similar lipophilicity to that of morpholine, based on the cLogP of a derived analogue. The first synthesis of morpholine 3a (tosylate salt) is described; the seven-step sequence begins with inexpensive starting materials and uses straightforward chemistry. Georg Thieme Verlag Stuttgart ? New York.
Synthesis of Optically Active N-Benzyl-2,4-Bis(hydroxymethyl) Substituted Azetidines by Lipase Catalyzed Acetylations
Guanti, Giuseppe,Riva, Renata
, p. 2921 - 2924 (2007/10/03)
Both cis- and trans-N-benzyl-azetidine-2,4-dimethanols 5 and 6 were prepared and submitted to acetylation in organic solvents catalyzed by lipases.Asymmetrization of diol 5 gave the corresponding monoacetate 7, while double sequential kinetic resolution of racemic 6 gave optically enriched diol 6b and its enantiomer as the corresponding diacetate 10a.Optimized reaction conditions furnished 7, 6b and 10a with e.e.>99percent.