174417-14-2

Basic information

• Product Name: 1H-Pyrrole-2-carboxylic acid, 4-(3,5-dichloro-2-hydroxybenzoyl)-, ethyl ester
• CAS NO: 174417-14-2
• Molecular Formula: C14H11Cl2NO4
• Molecular Weight: 328.152
• Mol File: 174417-14-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-2-carboxylic acid, 4-(3,5-dichloro-2-hydroxybenzoyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2-carboxylic acid, 4-(3,5-dichloro-2-hydroxybenzoyl)-, ethyl ester(174417-14-2)
• EPA Substance Registry System: 1H-Pyrrole-2-carboxylic acid, 4-(3,5-dichloro-2-hydroxybenzoyl)-, ethyl ester(174417-14-2)

Safety Data

• Hazardous Substances Data: 174417-14-2(Hazardous Substances Data)

Upstream product

• 2199-43-1 ethyl 1H-pyrrole-2-carboxylate 
• 22775-37-7 3,5-dichloro-2-methoxybenzoic acid 
• 5213-08-1 3,5-dichloro-2-methoxybenzoyl chloride 

Downstream Products

• 174417-16-4 4-(3,5-dichloro-2-hydroxybenzoyl)pyrrole-2-carboxylic acid 

Relevant articles and documents

β-Acylation of ethyl pyrrole-2-carboxylate by Friedel-Crafts acylation: Scope and limitations (synthetic studies on indoles and related compounds. XXXVIII

The Friedel-Crafts acylation of ethyl pyrrole-2-carboxylate (3) was studied under several conditions using various Lewis acids and acyl chlorides. The acylation with various acyl chlorides in the presence of aluminum chloride gave exclusively ethyl 4-acylpyrrole-2-carboxylate (5), whereas weaker Lewis acids such as zinc chloride and boron trifluoride etherate gave a mixture of ethyl 4- and 5-acylpyrrole-2-carboxylates.