174417-16-4

Basic information

• Product Name: 1H-Pyrrole-2-carboxylic acid, 4-(3,5-dichloro-2-hydroxybenzoyl)-
• CAS NO: 174417-16-4
• Molecular Formula: C12H7Cl2NO4
• Molecular Weight: 300.098
• Mol File: 174417-16-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-2-carboxylic acid, 4-(3,5-dichloro-2-hydroxybenzoyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2-carboxylic acid, 4-(3,5-dichloro-2-hydroxybenzoyl)-(174417-16-4)
• EPA Substance Registry System: 1H-Pyrrole-2-carboxylic acid, 4-(3,5-dichloro-2-hydroxybenzoyl)-(174417-16-4)

Safety Data

• Hazardous Substances Data: 174417-16-4(Hazardous Substances Data)

Upstream product

• 22775-37-7 3,5-dichloro-2-methoxybenzoic acid 
• 2199-43-1 ethyl 1H-pyrrole-2-carboxylate 
• 174417-14-2 ethyl 4-(3,5-dichloro-2-hydroxybenzoyl)pyrrole-2-carboxylate 

Relevant articles and documents

β-Acylation of ethyl pyrrole-2-carboxylate by Friedel-Crafts acylation: Scope and limitations (synthetic studies on indoles and related compounds. XXXVIII

The Friedel-Crafts acylation of ethyl pyrrole-2-carboxylate (3) was studied under several conditions using various Lewis acids and acyl chlorides. The acylation with various acyl chlorides in the presence of aluminum chloride gave exclusively ethyl 4-acylpyrrole-2-carboxylate (5), whereas weaker Lewis acids such as zinc chloride and boron trifluoride etherate gave a mixture of ethyl 4- and 5-acylpyrrole-2-carboxylates.