17449-02-4Relevant articles and documents
Synthesis of arylidene propanedioic acids by Knoevenagel condensation for use in ceramic sols
Shafqat, Syed Salman,Khan, Misbahul Ain,Zulkharnain, Azham,Hamdan, Sinin,Henry Rigit, Andrew Ragai,Khan, Amir Azam
, p. 8463 - 8466 (2014)
This paper is primarily concerned with the synthesis of arylidene propanedioic acids by Knoevenagel condensation. Generally organic bases pyridine and piperidine are used as catalyst in Knoevenagel condensation which are costly and health hazard. In this research work, Knoevenagel condensation of various aromatic aldehydes (benzaldehyde, salicylaldehyde and p-chlorobenzaldehyde) and active methylenes (malonic acid and ethyl acetoacetate) was carried out in the presence of amino acids (glycine, lysine, hippuric acid, methionine and leucine) as catalyst. Using salicylaldehyde gave coumarin-3-carboxylic acid, a solvent free synthesis. These products were isolated and purified and were characterized through melting points, TLC, IR, mass and 1H NMR. These acids are synthesized for eventual development of organically modified ceramic nano powders.
Knoevenagel condensation catalyzed by chemo-selective Ni-nanoparticles in neutral medium
Kumar, Ajeet,Dewan, Manika,Saxena, Amit,De, Arnab,Mozumdar, Subho
experimental part, p. 679 - 683 (2010/07/06)
Recyclable Ni-nanoparticles provides an efficient, economic and rapid method for catalyzing Knoevenagel condensation of aldehydes with an active methylene compound at room temperature. The method offers high yield preferably in case of aromatic aldehydes and proceed well in neutral medium. This method provides a wide range of substrate applicability and simple workup procedure. The products need no further purification and the process is environmentally benign.
Knoevenagel condensation catalyzed by USY zeolite
Wang,Ma, YuDao,Zuo, BoJun
, p. 4107 - 4110 (2007/10/03)
The Knoevenagel condensation of substituted benzaldehydes with active methylene compounds was performed very efficiently by using a USY (ultrastable Y) zeolite as heterogeneous catalyst.