24653-99-4

Basic information

• Product Name: 2,3-DIBROMO-3-(4-CHLOROPHENYL)PROPANOIC ACID
• Synonyms: P-CHLOROCINNAMIC ACID DIBROMIDE;TIMTEC-BB SBB008202;2,3-DIBROMO-3-(P-CHLOROPHENYL)PROPIONIC ACID;2,3-DIBROMO-3-(4-CHLOROPHENYL)PROPANOIC ACID;2,3-dibromo-3-(4-chlorophenyl)propionic acid;NSC 122941;α,β-DibroMo-4-chloro-benzenepropanoic Acid;alpha,beta-Dibromo-4-chlorobenzenepropanoic acid
• CAS NO: 24653-99-4
• Molecular Formula: C₉H₇Br₂ClO₂
• Molecular Weight: 342.41
• Product Categories: Aromatics Compounds;Aromatics
• Mol File: 24653-99-4.mol
• Article Data: 25

Chemical Properties

• Melting Point: 187℃
• Boiling Point: 357℃
• Flash Point: 170℃
• Appearance: Light yellow solid
• Density: 1.981
• Vapor Pressure: 1.01E-05mmHg at 25°C
• Refractive Index: 1.64
• Storage Temp.: 2-8°C
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: 2,3-DIBROMO-3-(4-CHLOROPHENYL)PROPANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIBROMO-3-(4-CHLOROPHENYL)PROPANOIC ACID(24653-99-4)
• EPA Substance Registry System: 2,3-DIBROMO-3-(4-CHLOROPHENYL)PROPANOIC ACID(24653-99-4)

Safety Data

• Hazardous Substances Data: 24653-99-4(Hazardous Substances Data)

Usage

Description

2,3-Dibromo-3-(4-chlorophenyl)propanoic acid, with the CAS number 24653-99-4, is a light yellow solid compound that is utilized in various organic synthesis processes. It is characterized by its unique chemical structure, which features two bromine atoms and a chlorine atom attached to a propanoic acid backbone. This structure endows the compound with specific reactivity and properties that make it valuable in the synthesis of other organic molecules.

Uses

Used in Organic Synthesis:
2,3-Dibromo-3-(4-chlorophenyl)propanoic acid is used as a synthetic intermediate for the production of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, such as substitution, addition, and elimination, which can lead to the formation of a diverse array of molecules with different applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,3-dibromo-3-(4-chlorophenyl)propanoic acid is used as a building block for the development of new drugs. Its chemical properties make it a versatile starting material for the synthesis of various drug candidates, particularly those targeting specific biological receptors or enzymes.
Used in Chemical Research:
2,3-Dibromo-3-(4-chlorophenyl)propanoic acid is also employed in chemical research as a model compound for studying various reaction mechanisms and exploring new synthetic methodologies. Its unique structure and reactivity provide researchers with valuable insights into the behavior of similar compounds and can lead to the discovery of novel synthetic routes and strategies.
Used in Agrochemical Industry:
In the agrochemical industry, 2,3-dibromo-3-(4-chlorophenyl)propanoic acid may be used as a precursor for the synthesis of various agrochemicals, such as pesticides and herbicides. Its chemical properties can be exploited to create molecules with specific biological activities that can be used to control pests and protect crops.
Used in Dye and Pigment Industry:
The light yellow color of 2,3-dibromo-3-(4-chlorophenyl)propanoic acid makes it a potential candidate for use in the dye and pigment industry. Its chemical structure can be modified to produce a range of colors, which can be used in various applications, such as textiles, plastics, and printing inks.

InChI:InChI=1/C9H7Br2ClO2/c10-7(8(11)9(13)14)5-1-3-6(12)4-2-5/h1-4,7-8H,(H,13,14)

Upstream product

• 1615-02-7 p-chlorocinnamic acid 
• 1615-02-7 3-(4-chlorophenyl)prop-2-enoic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 17449-02-4 p-chlorobenzylidenepropane-1,3-dioic acid 

Downstream Products

• 93666-26-3 α,β-dibromo-p-chlorohydrocinnamic acid chloride 
• 66482-30-2 (Z)-1-bromo-2-(4-chlorophenyl)ethylene 
• 42393-39-5 (Z)-2-bromo-3-(4-chlorophenyl)propenoic acid 
• 105072-48-8 (E)-2-bromo-3-(4-chlorophenyl)propenoic acid 
• 66482-29-9 1-[(E)-2-bromoethenyl]-4-chlorobenzene 
• 93696-58-3 3-Bromo-4-(4-chloro-phenyl)-6-methyl-3,4-dihydro-1H-quinolin-2-one 
• 93696-63-0 4-(4-Chloro-phenyl)-6-methyl-1H-quinolin-2-one 
• 93500-95-9 2,3-Dibromo-3-(4-chloro-phenyl)-N-phenyl-propionamide 
• 93501-00-9 2,3-Dibromo-3-(4-chloro-phenyl)-propionic acid phenyl ester 
• 93500-96-0 2,3-Dibromo-3-(4-chloro-phenyl)-N-p-tolyl-propionamide 
• 93501-01-0 2,3-Dibromo-3-(4-chloro-phenyl)-propionic acid p-tolyl ester 
• 5676-62-0 (Z)-3-(4-chlorophenyl)acrylic acid 
• 87212-85-9 C₁₆H₁₂Cl₂ 
• 3240-10-6 (4-chlorophenyl)propiolic acid 

Relevant articles and documents

Synthesis method of o-Dibromo compound

The present invention discloses a synthesis method of o-dibromo compounds, said synthesis method comprising the following steps: preparation of olefins, brominated salts and a mixed solution of bromate; to the mixed solution of dropwise addition of hydrochloric acid solution for reaction; to the end of the reaction, the extraction of o-dibromo compounds in the reaction product; the synthesis method to inexpensive brominated salts (industrial or recycled brominated salts) and bromate as a bromine source, enhance the full use of applicable resources; after the end of the reaction after a simple filtration treatment to obtain a sufficient purity of the product, It can reduce production costs; at the same time, facilitate the transportation and storage of raw materials, and improve the working environment. The synthesis method of the present invention is simple and easy to operate, high safety, small pollution, simple post-treatment, low production cost, product yield and purity can meet the production needs, is both cost advantages and safety and environmental advantages of the industrializable process.

Chloro/bromotrimethylsilane-Cu(NO3)2·3H2O: Safe and efficient reagent system for the decarboxylative ipso-nitration and dibromination of cinnamic acids

Further synthetic potential of halotrimethylsilane-nitrate salt mixture is revealed. A mixture of TMSX-Cu(NO3)2·3H2O system is found to be an efficient reagent system for both the decarboxylative nitration (ipso-nitration) when X?=?Cl, and dibromination of cinnamic acids, with X?=?Br, under mild conditions. The reactions are safe and simple, affording the corresponding products (E)-β-nitrostyrenes, and anti-2,3-dibromo-3-phenylpropanoic acids in high yields with high selectivity in a relatively short time. Use of hazardous and toxic nitrating systems such as acetyl nitrate and brominating agents such as molecular bromine can be avoided.

Engaging Alkenyl Halides with Alkylsilicates via Photoredox Dual Catalysis

Single-electron transmetalation via photoredox/nickel dual catalysis provides the opportunity for the construction of Csp3-Csp2 bonds through the transfer of alkyl radicals under very mild reaction conditions. A general procedure for the cross-coupling of primary and secondary (bis-catecholato)alkylsilicates with alkenyl halides is presented. The developed method allows not only alkenyl bromides and iodides but also previously underexplored alkenyl chlorides to be employed. (Chemical Equation Presented).