174649-06-0Relevant articles and documents
An azido-oxazolidinone antibiotic for live bacterial cell imaging and generation of antibiotic variants
Phetsang, Wanida,Blaskovich, Mark A.T.,Butler, Mark S.,Huang, Johnny X.,Zuegg, Johannes,Mamidyala, Sreeman K.,Ramu, Soumya,Kavanagh, Angela M.,Cooper, Matthew A.
, p. 4490 - 4498 (2014/09/17)
An azide-functionalised analogue of the oxazolidinone antibiotic linezolid was synthesised and shown to retain antimicrobial activity. Using facile 'click' chemistry, this versatile intermediate can be further functionalised to explore antimicrobial structure-activity relationships or conjugated to fluorophores to generate fluorescent probes. Such probes can report bacteria and their location in a sample in real time. Modelling of the structures bound to the cognate 50S ribosome target demonstrates binding to the same site as linezolid is possible. The fluorescent probes were successfully used to image Gram-positive bacteria using confocal microscopy.
BORON CONTAINING SMALL MOLECULES
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, (2011/04/24)
This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
Synthesis and antibacterial activities of eperezolid analogs with glycinyl substitutions
Wang, Xiao-Jun,Wu, Ning,Du, Guang-Jian,Zhao, Shuang-Qi,Yan, Ming,Gu, Lian-Quan
scheme or table, p. 377 - 385 (2009/10/23)
A series of eperezolid analogs with glycinyl substitutions were prepared and their antibacterial activities were studied against a panel of susceptible and resistant Gram-positive bacteria. The compounds with N-arylacyl or N-heteroarylacyl glycinyl struct
