174649-08-2

Basic information

• Product Name: Acetamide, N-[[3-[3-fluoro-4-[4-[(phenylmethoxy)acetyl]-1-piperazinyl]phenyl]-2-oxo- 5-oxazolidinyl]methyl]-, (S)-
• CAS NO: 174649-08-2
• Molecular Formula: C25H29FN4O5
• Molecular Weight: 484.527
• Mol File: 174649-08-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[[3-[3-fluoro-4-[4-[(phenylmethoxy)acetyl]-1-piperazinyl]phenyl]-2-oxo- 5-oxazolidinyl]methyl]-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[[3-[3-fluoro-4-[4-[(phenylmethoxy)acetyl]-1-piperazinyl]phenyl]-2-oxo- 5-oxazolidinyl]methyl]-, (S)-(174649-08-2)
• EPA Substance Registry System: Acetamide, N-[[3-[3-fluoro-4-[4-[(phenylmethoxy)acetyl]-1-piperazinyl]phenyl]-2-oxo- 5-oxazolidinyl]methyl]-, (S)-(174649-08-2)

Safety Data

• Hazardous Substances Data: 174649-08-2(Hazardous Substances Data)

Upstream product

• 19810-31-2 Benzyloxyacetyl chloride 
• 154590-66-6 (S)-N-[[3-[3-fluoro-4-(1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 
• 174649-05-9 (S)-N-[[3-[3-fluoro-4-[4-carbobenzoxypiperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide 
• 903594-02-5 4-[2-Fluoro-4-((R)-5-methanesulfonyloxymethyl-2-oxo-oxazolidin-3-yl)-phenyl]-piperazine-1-carboxylic acid benzyl ester 
• 174649-03-7 N-carbobenzoxy-3-fluoro-4-(N-carbobenzoxypiperazin-1-yl)aniline 
• 198410-25-2 (S)-N-(3-(3-fluoro-4-((N-4-carbobenzoxy)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methylamine 
• 174649-04-8 (R)-[N-3-[3-fluoro-4-[N-1-(4-carbobenzoxy)piperazinyl]-phenyl]-2-oxo-5-oxazolidinyl]methanol 
• 183905-31-9 N-[(2S)-2-acetoxy-3-chloropropyl]acetamide 
• 183805-10-9 N-[(2S)oxiranylmethyl]acetamide 
• 174649-06-0 (S)-N-[[3-[3-fluoro-4-[N-1-(4-carbobenzoxy)piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 

Downstream Products

• 912552-58-0 4-{4-[benzyloxycarbonyl-(3-oxo-propyl)-amino]-2-fluoro-phenyl}-piperazine-1-carboxylic acid benzyl ester 
• 912552-57-9 4-{4-[benzyloxycarbonyl-(3-hydroxy-propyl)-amino]-2-fluoro-phenyl}-piperazine-1-carboxylic acid benzyl ester 
• 912552-59-1 4-{4-[Benzyloxycarbonyl-((S)-2,3-dihydroxy-propyl)-amino]-2-fluoro-phenyl}-piperazine-1-carboxylic acid benzyl ester 
• 174649-04-8 (R)-[N-3-[3-fluoro-4-[N-1-(4-carbobenzoxy)piperazinyl]-phenyl]-2-oxo-5-oxazolidinyl]methanol 
• 198410-25-2 (S)-N-(3-(3-fluoro-4-((N-4-carbobenzoxy)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methylamine 
• 903594-02-5 4-[2-Fluoro-4-((R)-5-methanesulfonyloxymethyl-2-oxo-oxazolidin-3-yl)-phenyl]-piperazine-1-carboxylic acid benzyl ester 
• 239438-48-3 (R)-[N-3-[3-fluoro-4-[N-1-(4-carbobenzoxy)piperazinyl]-phenyl]-2-oxo-5-oxazolidinyl]methyl azide 
• 165800-04-4 eperezolid 

Relevant articles and documents

Short and practical enantioselective synthesis of linezolid and eperezolid via proline-catalyzed asymmetric α-aminooxylation

An efficient enantioselective synthesis of the antibacterials, linezolid (U-100766), and eperezolid (U-100592) using d-proline-catalyzed asymmetric α-aminooxylation of aldehydes as the key step is described here. This is the first report on the enantioselective synthesis of linezolid and eperezolid using asymmetric catalysis.

Dynamic kinetic resolution of epichlorohydrin via enantioselective catalytic ring opening with TMSN3. Practical synthesis of aryl oxazolidinone antibacterial agents

The dynamic kinetic resolution of racemic epichlorohydrin has been achieved via enantioselective asymmetric ring opening with TMSN3 catalyzed by the (salen)Cr(III)N3 complex 1. The resulting 3-azido-1-chloro-2-trimethylsiloxypropane product was obtained in high enantiomeric purity and incorporated into the synthesis of U-100592, a representative from a class of highly-promising aryl oxazolidinone antibacterial agents.