17473-78-8

Basic information

• Product Name: Acetic acid,2-(4-methoxyphenyl)hydrazide
• Synonyms: Aceticacid, 2-(p-methoxyphenyl)hydrazide (8CI); NSC 38543;N'-(4-Methoxyphenyl)acetohydrazide
• CAS NO: 17473-78-8
• Molecular Formula: C9H12 N2 O2
• Molecular Weight: 180.206
• Mol File: 17473-78-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Acetic acid,2-(4-methoxyphenyl)hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid,2-(4-methoxyphenyl)hydrazide(17473-78-8)
• EPA Substance Registry System: Acetic acid,2-(4-methoxyphenyl)hydrazide(17473-78-8)

Safety Data

• Hazardous Substances Data: 17473-78-8(Hazardous Substances Data)

Upstream product

• 64-19-7 acetic acid 
• 3471-32-7 4-Methoxyphenylhydrazine 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 108-24-7 acetic anhydride 
• 104-94-9 4-methoxy-aniline 
• 17333-79-8 p-methoxybenzenediazonium 
• 431-03-8 dimethylglyoxal 

Downstream Products

• 681860-22-0 N,N'-dimethyl-N'-(4-methoxyphenyl)acetohydrazide 
• 104431-00-7 C₁₁H₁₂N₂O₂ 
• 1443786-98-8 1-(4-methoxyphenyl)-5-(p-tolyl)-1H-1,2,4-triazol-3-amine 
• 1616351-55-3 dimethyl 1-(4-methoxyphenyl)-5-methyl-1H-pyrazole-3,4-dicarboxylate 
• 141330-39-4 N-acetyl-N’-(4-methoxyphenyl)acetohydrazide 
• 1694-19-5 E-1-(phenyl)-2-(4'-methoxyphenyl)ethene 
• 88530-86-3 5-methoxy-2,3-diphenyl-1H-indole 
• 2731-01-3 (±)-5-methoxy-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo-[2,3-b]indole 
• 412284-09-4 3-ethyl-1,2-dimethyl-5-methoxyindole 
• 1450812-53-9 N'-(4-methoxyphenyl)-N'-methylacetohydrazide 
• 19234-04-9 2-(p-methoxyphenyl)-benzo[b]furan 
• 134804-66-3 6-hydroxy-4-methoxy-2-phenylbenzofuran 

Relevant articles and documents

Fischer Reaction with 2-Perfluoroalkylated Cyclic Imines - An Efficient Route to 2-Perfluoroalkyl-Substituted Tryptamines and Their Derivatives and Homologues

The reaction of 2-perfluoroalkyl-substituted cyclic imines with arylhydrazines was investigated. We found that 2-perfluoroalkylated cyclic imines are highly reactive electrophiles that form, through ring opening, the corresponding hydrazones bearing an amine group at the end of the alkyl chain. Subsequent acidic treatment resulted in a Fischer rearrangement. Thus, a new synthesis of 2-perfluoroalkylated tryptamines and their homologues through a Fischer reaction was developed. The possibility of modification of the indole core of the 2-CF3-substituted tryptamine products was demonstrated, and various 2-trifluoromethylated tryptamines substituted at the 5-position were prepared. An efficient method for the synthesis of CF3-substituted tryptamines was developed based on the Fischer reaction of perfluoroalkyl-substituted cyclic imines with arylhydrazines. A 5-bromotryptamine was also transformed into further derivatives.

Rh(III)-catalyzed oxidative coupling of 1,2-disubstituted arylhydrazines and olefins: A new strategy for 2,3-dihydro-1H-indazoles

A rhodium(III)-catalyzed oxidative olefination of 1,2-disubstituted arylhydrazines with alkenes via sp2 C-H bond activation followed by an intramolecular aza-Michael reaction is described. This strategy allows the direct and efficient construct

Formation of enehydrazine intermediates through coupling of phenylhydrazines with vinyl halides: Entry into the Fischer indole synthesis

Cut to the chase: Direct formation of an enehydrazine, an intermediate in the classic Fischer indole synthesis, solves the regioselectivity problem associated with indolization. This approach not only achieves selective synthesis of indoles through proper selection of the vinyl halide, but also leads to quick construction of desoxyeseroline and esermethole, as well as the key structural motif in the Akuammiline alkaloid vincorine. Copyright