2731-01-3Relevant articles and documents
Photocatalytic Cascade Radical Cyclization Approach to Bioactive Indoline-Alkaloids over Donor-Acceptor Type Conjugated Microporous Polymer
Ou, Wei,Zhang, Guoqiang,Wu, Jie,Su, Chenliang
, p. 5178 - 5183 (2019/05/24)
Herein, we describe a visible-light-induced radical strategy for the 1,2-formylarylation of N-arylacrylamides via the C-H activation of 1,3-dioxolane using a carbazolic-cyano conjugated microporous polymer (CC-CMP) as a metal-free photocatalyst. This process provides an efficient and mild approach for constructing highly functionalized formyl-substituted oxindoles, which are valuable building blocks that allow rapid access to various important heterocycle-fused and spirocyclic indole alkaloids. Utilizing this strategy, bioactive alkaloids, such as (±)-desoxyeseroline, (±)-esermethole, and (±)-N-Me-coerulescine, have been concisely synthesized in up to 74% overall yield from low-cost acrylamides and 1,3-dioxolane. The overall yields of our approach are much higher than those of conventional multistep methods. Gram-scale syntheses of natural alkaloids have been demonstrated, highlighting the practical utility of this protocol. The use of CC-CMP photocatalysts, which are metal-free, flexible, stable, effective, and reusable, making this strategy appealing to advanced chemical manufacturing.
The photocatalysis synthetic alkaloid (by machine translation)
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Paragraph 0126; 0127; 0128, (2018/11/22)
The present invention provides a catalytic synthesis method of living beings, the alkaloid comprises indole fused ring class and indole spiro compound, the process is as follows: in order to nitrogen aryl acrylamide as raw materials in under the photocatalysis with peroxide synthesis 3 - acetal 2 - indole compound, obtained through hydrolysis 3 - formyl - 2 - indole compound, further reducing synthetic alkaloid, the method routes mild, efficiency is high-efficient. The reaction in the illumination can occur under the room temperature, mild condition, has better substrate versatility and functional group tolerant. (by machine translation)
Synthesis of C3-Methyl-Substituted Pyrroloindolines and Furoindolines via Cascade Dearomatization of Indole Derivatives with Methyl Iodide
Yi, Ji-Cheng,Liu, Chuan,Dai, Li-Xin,You, Shu-Li
supporting information, p. 2975 - 2979 (2017/11/14)
A highly efficient method for constructing C3-methyl-substituted pyrroloindolines and furoindolines via cascade dearomatization reaction of indole derivatives with methyl iodide was developed. This protocol offers a direct approach to a wide range of C3 methyl substituted pyrroloindolines under mild conditions. The utility of this method was further demonstrated in the concise synthesis of (±)-esermethol.
