128368-43-4

Basic information

• Product Name: Benzenamine, 4-methoxy-2-(1-methylethenyl)-
• CAS NO: 128368-43-4
• Molecular Formula: C10H13NO
• Molecular Weight: 163.219
• Mol File: 128368-43-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzenamine, 4-methoxy-2-(1-methylethenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-methoxy-2-(1-methylethenyl)-(128368-43-4)
• EPA Substance Registry System: Benzenamine, 4-methoxy-2-(1-methylethenyl)-(128368-43-4)

Safety Data

• Hazardous Substances Data: 128368-43-4(Hazardous Substances Data)

Upstream product

• 89433-06-7 2-(2-amino-5-methoxyphenyl)propan-2-ol 
• 23042-77-5 1-(2-amino-5-methoxy-phenyl)-ethanone 
• 2475-80-1 methyl 2-amino-5-methoxybenzoate 
• 75-16-1 methylmagnesium bromide 
• 104-94-9 4-methoxy-aniline 
• 18437-68-8 tert-butyl N-(4-methoxyphenyl)carbamate 
• 157496-75-8 tert-butyl (2-iodo-4-methoxyphenyl)carbamate 
• 1426832-63-4 C₁₅H₂₁NO₃ 
• 32338-02-6 2-bromo-4-methoxyaniline 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 23842-82-2 2-amino-5-methoxybenzonitrile 

Downstream Products

• 1208117-70-7 (4-methoxy-2-(prop-1-en-2-yl)phenyl)carbamoyl cyanide 
• 2731-01-3 (±)-5-methoxy-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo-[2,3-b]indole 
• 1208117-72-9 C₁₁H₁₅NO 
• 5342-23-4 6-methoxy-4-methyl-2-oxo-1H-quinoline 
• 62851-43-8 zidometacin 
• 53-86-1 [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid 
• 1601-18-9 indomethacin methyl ester 
• 6260-97-5 (4-chlorophenyl)(5-methoxy-2-methyl-1H-indol-1-yl)methanone 
• 128368-45-6 [(2-Isopropenyl-4-methoxy-phenyl)-methoxycarbonyl-amino]-acetic acid methyl ester 
• 128368-46-7 [(2-Isopropenyl-4-methoxy-phenyl)-methoxycarbonyl-amino]-acetic acid 
• 675578-56-0 N-allyl-N-acetyl-2-isopropenyl-4-methoxyaniline 
• 128368-44-5 (2-Isopropenyl-4-methoxy-phenyl)-carbamic acid methyl ester 

Relevant articles and documents

Palladium-Catalyzed Carbamoyl-Carbamoylation/ Carboxylation/Thioesterification of Alkene-Tethered Carbamoyl Chlorides Using Mo(CO)6 as the Carbonyl Source

We reported a palladium-catalyzed carbamoyl-carbamoylation/carboxylation/thioesterification of alkene-tethered carbamoyl chlorides using Mo(CO)6 as the carbonyl source. The reactions were typically performed with good functional group compatibility and tolerated different nucleophiles (amines, alcohols, phenols, thiols and water), which provided a new access to amidated/esterificated/thioesterificated/carboxylated oxindoles or lactams bearing an all-carbon quaternary stereocenter under CO gas-free conditions. Furthermore, natural product mutation and divergent late-stage derivatization are the important practical features.

Enantioselective Intramolecular Copper-Catalyzed Borylacylation

An enantioselective copper-catalyzed intramolecular borylacylation is reported. The reaction proceeds through an initial enantioselective borylcupration of the styrene, followed by a nucleophilic attack on the tethered carbamoyl chloride. The products, chiral borylated 3,3-disubstituted oxindoles, were generated in excellent yields and enantioselectivities. The versatile carbon–boron bond provides a platform for a wide array of diversification.

Synthesis of (±)-esermethole via an intramolecular carbamoylketene-alkene [2+2] cycloaddition

A synthesis of (±)-esermethole (2), a synthetic precursor of physostigmine (1), has been accomplished by using an intramolecular carbamoylketene-alkene [2+2] cycloaddition followed by nitrone-mediated regioselective ring expansion for the construction of the basic carbon framework of 2 as the key steps.