174874-85-2

Basic information

• Product Name: (2R,3S)-2-(3-acetoxy-1-benzyl-5-oxo-pyrrolidin-2-yl)-3-oxo-butyric acid methyl ester
• Synonyms: (2R,3S)-2-(3-acetoxy-1-benzyl-5-oxo-pyrrolidin-2-yl)-3-oxo-butyric acid methyl ester
• CAS NO: 174874-85-2
• Molecular Weight: 347.368
• Mol File: 174874-85-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,3S)-2-(3-acetoxy-1-benzyl-5-oxo-pyrrolidin-2-yl)-3-oxo-butyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-2-(3-acetoxy-1-benzyl-5-oxo-pyrrolidin-2-yl)-3-oxo-butyric acid methyl ester(174874-85-2)
• EPA Substance Registry System: (2R,3S)-2-(3-acetoxy-1-benzyl-5-oxo-pyrrolidin-2-yl)-3-oxo-butyric acid methyl ester(174874-85-2)

Safety Data

• Hazardous Substances Data: 174874-85-2(Hazardous Substances Data)

Upstream product

• 59025-03-5 (S)-acetoxysuccinic anhydride 
• 62269-44-7 methyl 3-trimethylsiloxybut-2-enoate 
• 133005-21-7 acetic acid (2S,3S)-2-acetoxy-1-benzyl-5-oxo-pyrrolidin-3-yl ester 
• 129823-21-8 (S)-4-acetoxy-1-benzyl-2,5-pyrrolidinedione 
• 132917-66-9 acetic acid (2S,3S)-1-benzyl-2-hydroxy-5-oxo-pyrrolidin-3-yl ester 

Downstream Products

• 123-54-6 acetylacetone 

Relevant articles and documents

Studies towards the synthesis of (+)-ptilomycalin A; stereoselective N-acyliminium ion coupling reactions to enantiopure C-2 substituted lactams

Highly stereoselective N-acyliminium ion coupling reactions of β-ketoester derived silyl enol ethers with enantiopure lactams derived from (S)-malic acid are reported. This reaction type is applied in the synthesis of the enantiopure C-2 substituted lactam 27, a plausible intermediate in a projected synthesis of ptilomycalin A.