17504-13-1

Basic information

• Product Name: methyl 4-hydroxy-[1,1’-biphenyl]-3-carboxylate
• Synonyms: methyl 4-hydroxy-[1,1’-biphenyl]-3-carboxylate
• CAS NO: 17504-13-1
• Molecular Weight: 228.247
• Mol File: 17504-13-1.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: methyl 4-hydroxy-[1,1’-biphenyl]-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-hydroxy-[1,1’-biphenyl]-3-carboxylate(17504-13-1)
• EPA Substance Registry System: methyl 4-hydroxy-[1,1’-biphenyl]-3-carboxylate(17504-13-1)

Safety Data

• Hazardous Substances Data: 17504-13-1(Hazardous Substances Data)

Upstream product

• 2150-46-1 Methyl 2,5-dihydroxybenzoate 
• 98-80-6 phenylboronic acid 
• 108-86-1 bromobenzene 
• 1261270-09-0 4-hydroxy-3-(methoxycarbonyl)benzenediazonium tetrafluoroborate 
• 100-58-3 phenylmagnesium bromide 
• 603-33-8 triphenylbismuthane 
• 80234-04-4 2-phenylacrylaldehyde diethyl acetal 
• 105-45-3 acetoacetic acid methyl ester 
• 64810-21-5 2-Hydroxy-5-phenyl-cyclohex-1-enecarboxylic acid methyl ester 
• 22717-57-3 methyl 6-hydroxy-m-toluate 
• 108-90-7 chlorobenzene 
• 92-69-3 4-Phenylphenol 
• 40757-09-3 methyl 2-methoxy-5-iodobenzoate 
• 4068-75-1 methyl 5-iodosalicylate 

Downstream Products

• 1373438-77-7 4-hydroxy-N'-[(1E)-1-(1H-indol-2-yl)ethylidene]-1,1'-biphenyl-3-carbohydrazide 
• 63906-81-0 4-(2-hydroxy-ethoxy)-biphenyl-3-carboxylic acid methylamide 
• 77527-02-7 C₁₇H₁₂O₄ 
• 77527-33-4 C₁₆H₁₂O₂ 
• 50781-46-9 2-phenyl-9H-xanthen-9-one 
• 867218-37-9 4-{3,5-difluoro-4-(1-methyl-3-phenyl-propylamino)-6-[3-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenoxy]-pyridin-2-yloxy}-biphenyl-3-carboxylic acid methyl ester 
• 323-87-5 4-hydroxybiphenyl-3-carboxylic acid 
• 77526-94-4 4-(2-Oxo-tetrahydro-furan-3-yloxy)-biphenyl-3-carboxylic acid methyl ester 

Relevant articles and documents

Tuning transthyretin amyloidosis inhibition properties of iododiflunisal by combinatorial engineering of the nonsalicylic ring substitutions

Two series of iododiflunisal and diflunisal analogues have been obtained by using a two step sequential reaction solution-phase parallel synthesis. The synthesis combined an aqueous Suzuki-Miyaura cross-coupling and a mild electrophilic aromatic iodination step using a new polymer-supported iodonium version of Barluengas reagent. From a selected set of 77 noniodinated and 77 iodinated diflunisal analogues, a subset of good transthyretin amyloid inhibitors has been obtained with improved turbidimetry inhibition constants, high binding affinity to transthyretin, and good selectivity for TTR compared to other thyroxine binding proteins.

Iridium(III)-Catalyzed Intermolecular C(sp3)?H Insertion Reaction of Quinoid Carbene: A Radical Mechanism

Described herein is an IrIII/porphyrin-catalyzed intermolecular C(sp3)?H insertion reaction of a quinoid carbene (QC). The reaction was designed by harnessing the hydrogen-atom transfer (HAT) reactivity of a metal-QC species with aliphatic substrates followed by a radical rebound process to afford C?H arylation products. This methodology is efficient for the arylation of activated hydrocarbons such as 1,4-cyclohexadienes (down to 40 min reaction time, up to 99 % yield, up to 1.0 g scale). It features unique regioselectivity, which is mainly governed by steric effects, as the insertion into primary C?H bonds is favored over secondary and/or tertiary C?H bonds in the substituted cyclohexene substrates. Mechanistic studies revealed a radical mechanism for the reaction.

Rhodium(ii)-catalysed generation of cycloprop-1-en-1-yl ketones and their rearrangement to 5-aryl-2-siloxyfurans

Donor-acceptor cyclopropenes formed from enoldiazoketones undergo catalytic rearrangement to 5-aryl-2-siloxyfurans via a novel mechanism that involves a nucleophilic addition of the carbonyl oxygen to the rhodium-activated cyclopropene.