50781-46-9

Basic information

• Product Name: 9H-Xanthen-9-one, 2-phenyl-
• CAS NO: 50781-46-9
• Molecular Formula: C19H12O2
• Molecular Weight: 272.303
• Mol File: 50781-46-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 9H-Xanthen-9-one, 2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-Xanthen-9-one, 2-phenyl-(50781-46-9)
• EPA Substance Registry System: 9H-Xanthen-9-one, 2-phenyl-(50781-46-9)

Safety Data

• Hazardous Substances Data: 50781-46-9(Hazardous Substances Data)

Upstream product

• 57279-20-6 1-(2-bromophenyl)-butane-1,3-dione 
• 80234-04-4 2-phenylacrylaldehyde diethyl acetal 
• 934691-77-7 2-(biphenyl-4-yloxy)benzaldehyde 
• 92-69-3 4-Phenylphenol 
• 446-52-6 2-Fluorobenzaldehyde 
• 56341-31-2 2-bromo-9H-xanthene-9-one 
• 98-80-6 phenylboronic acid 
• 90-47-1 xanth-9-one 
• 17504-13-1 methyl 4-hydroxy-[1,1’-biphenyl]-3-carboxylate 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 

Downstream Products

• 1316277-24-3 C₁₉H₁₃NO₂ 
• 1316277-18-5 C₁₉H₁₃NO₂ 
• 1316277-36-7 C₁₉H₁₃NO₃ 
• 1316277-31-2 C₁₉H₁₃NO₃ 
• 1323153-39-4 2-hydroxy-5-phenyl-2'-hydroxybenzophenone 
• 1323153-54-3 C₂₆H₂₀N₂O₃ 

Relevant articles and documents

Formation and Disproportionation of Xanthenols to Xanthenes and Xanthones and Their Use in Synthesis

A facile and versatile strategy employing TiCl4-mediated cyclization followed by a Cannizzaro reaction has been developed for the synthesis of various xanthene derivatives. The reaction proceeded smoothly to afford both xanthenes/xanthones or their sulfur derivatives and tolerated a wide range of electronically diverse substrates. Using this methodology, pranoprofen was synthesized in three steps in 59% overall yield from commercially available starting materials.

Oxidative [3+3] Annulation of Atropaldehyde Acetals with 1,3-Bisnucleophiles: An Efficient Method of Constructing Six-Membered Aromatic Rings, Including Salicylates and Carbazoles

An oxidative [3+3] annulation of atropaldehyde acetals with various 1,3-bisnucleophiles was developed using either N-bromosuccinimide or copper(II) bromide as oxidizing reagent and Br?nsted or Lewis acids as catalyst. The [3+3] annulations can be considered mechanistically as oxidizing reagent-induced acid-acid-catalyzed domino reactions established through the concept of auto-tandem catalysis. Alkyl acetoacetates, α-(indol-2-yl)acetate, anilines, 1-methyl-1H-pyrazol-3-amine, ethyl 5-amino-1H-pyrazole-3-carboxylate, and 3-amino-1H-indazole can all be used as 1,3-bisnucleophiles in this type of transformation. The established reactions can very efficiently construct six-membered aromatic rings, including salicylates and carbazoles. A four-step method of synthesizing the anti-inflammatory agent diflunisal was also developed based on the oxidative [3+3] annulation reaction, and the yield was high. (Figure presented.).

FeCl3 and ether mediated direct intramolecular acylation of esters and their application in efficient preparation of xanthone and chromone derivatives

The direct intramolecular acylation of esters was developed by using the combined system of FeCl3 with Cl2CHOCH3. This unique cooperative system offered a new and efficient approach to biologically important xanthone and chromone derivatives with regioselectivity. Examples were reported, and control experiments were carried out to examine the effect of the benzyl esters and Cl2CHOCH3.